Robust, flexible, and scalable tests for Hardy-Weinberg Equilibrium across diverse ancestries.
Sign Up to like & getrecommendations! Published in 2021 at "Genetics"
DOI: 10.1093/genetics/iyab044
Abstract: Traditional Hardy-Weinberg equilibrium (HWE) tests (the χ2 test and the exact test) have long been used as a metric for evaluating genotype quality, as technical artifacts leading to incorrect genotype calls often can be identified… read more here.
Keywords: weinberg equilibrium; hardy weinberg; diverse ancestries; hwe ... See more keywords
Asymptotic tests for Hardy–Weinberg equilibrium in hexaploids
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DOI: 10.1093/hr/uhac104
Abstract: Abstract Hexaploids, a group of organisms containing three complete sets of chromosomes in a single nucleus, are of utmost importance to evolutionary studies and breeding programs. Many studies have focused on hexaploid linkage analysis and… read more here.
Keywords: hardy weinberg; weinberg equilibrium; asymptotic tests; equilibrium hexaploids ... See more keywords
Multi‐allelic exact tests for Hardy–Weinberg equilibrium that account for gender
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DOI: 10.1111/1755-0998.12748
Abstract: Statistical tests for Hardy–Weinberg equilibrium are important elementary tools in genetic data analysis. X‐chromosomal variants have long been tested by applying autosomal test procedures to females only, and gender is usually not considered when testing… read more here.
Keywords: weinberg equilibrium; hardy weinberg; gender; equilibrium ... See more keywords
Extending Tests of Hardy-Weinberg Equilibrium to Structured Populations.
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DOI: 10.1534/genetics.119.302370
Abstract: Testing for Hardy-Weinberg Equilibrium (HWE) is an important component in almost all analyses of population genetic data. Genetic markers that violate HWE are often treated as special cases; for example, they may be flagged as… read more here.
Keywords: weinberg equilibrium; hardy weinberg; structure; test ... See more keywords
Comment on three papers about Hardy–Weinberg equilibrium tests in autopolyploids
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1027209
Abstract: One goal in the population genetics of autopolyploids, which are organisms with more than two sets of homologous chromosomes, is to model their genotype frequencies. This modeling presents a greater challenge in autopolyploids than in… read more here.
Keywords: random mating; hardy weinberg; weinberg equilibrium; genotype frequencies ... See more keywords