Unexpected decarboxamidation of α-arylsulfonyl Weinreb amides by Grignard reagents: Synthesis of α-disubstituted arylsulfones
Sign Up to like & getrecommendations! Published in 2017 at "Chemical Research in Chinese Universities"
DOI: 10.1007/s40242-017-6371-z
Abstract: An unexpected decarboxamidation of α-arylsulfonyl Weinreb amides as a side reaction under the standard acylating conditions was found in Weinreb amides chemistry. The control experiments for mechanism study disclosed that α-sulfo group was necessary, and… read more here.
Keywords: unexpected decarboxamidation; weinreb amides; arylsulfonyl weinreb; decarboxamidation arylsulfonyl ... See more keywords
Ligand-Enabled, Palladium-Catalyzed β-C(sp3)-H Arylation of Weinreb Amides.
Sign Up to like & getrecommendations! Published in 2018 at "ACS catalysis"
DOI: 10.1021/acscatal.8b03014
Abstract: We report the development of Pd(II)-catalyzed C(sp3)-H arylation of Weinreb amides. This work demonstrates the first example of using Weinreb amide as a directing group for transition metal-catalyzed C(sp3)-H activation. Both the inductive effect and… read more here.
Keywords: arylation weinreb; weinreb; catalyzed sp3; weinreb amides ... See more keywords
One-pot synthesis of Weinreb amides employing 3,3-dichloro-1,2-diphenylcyclopropene (CPI-Cl) as a chlorinating agent
Sign Up to like & getrecommendations! Published in 2019 at "Synthetic Communications"
DOI: 10.1080/00397911.2018.1531295
Abstract: Abstract The synthesis of Nα-protected amino alkyl Weinreb amides starting from the corresponding α-amino acids as well as carboxylic acids has been delineated through the in situ generation of acid chlorides using CPI-Cl as a… read more here.
Keywords: chlorinating agent; weinreb amides; synthesis; cpi chlorinating ... See more keywords