Predicting Clearance with Simple and Permeability-Limited Physiologically Based Pharmacokinetic Frameworks: Comparison of Well-Stirred, Dispersion, and Parallel-Tube Liver Models
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DOI: 10.1124/dmd.124.001782
Abstract: One-compartment (1C) and permeability-limited models were used to evaluate the ability of microsomal and hepatocyte intrinsic clearances to predict hepatic clearance. Well-stirred (WSM), parallel-tube (PTM), and dispersion (DM) models were evaluated within the liver as… read more here.
Keywords: parallel tube; permeability; clearance; permeability limited ... See more keywords
Qualitative Study of a Well-Stirred Isothermal Reaction Model
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DOI: 10.3390/math8060938
Abstract: We consider a two-dimensional system which is a mathematical model for a temporal evolution of a well-stirred isothermal reaction system. We give sufficient conditions for the existence of purely imaginary eigenvalues of the Jacobian matrix… read more here.
Keywords: stirred isothermal; system; isothermal reaction; well stirred ... See more keywords