Elevated YKL-40 serum levels may contribute to wet age-related macular degeneration via the ERK1/2 pathway.
Sign Up to like & getrecommendations! Published in 2021 at "FEBS open bio"
DOI: 10.1002/2211-5463.13223
Abstract: Choroidal neovascularization (CNV) is a key characteristic of wet age-related macular degeneration (AMD) that can lead to severe vision loss in the elderly. Anti-VEGF therapy is currently the premier strategy for wet AMD, but it… read more here.
Keywords: age related; erk1 pathway; wet age; wet amd ... See more keywords
The fate of eyes with wet AMD beyond four years of anti-VEGF therapy
Sign Up to like & getrecommendations! Published in 2018 at "Graefe's Archive for Clinical and Experimental Ophthalmology"
DOI: 10.1007/s00417-018-3907-y
Abstract: PurposeReal-life studies on long-term functional outcome of anti-VEGF treatment for wet age-related macular degeneration (wAMD) are limited. We therefore assessed the 10-year outcomes in our patients.MethodsIn this retrospective study, all patients with newly diagnosed wAMD… read more here.
Keywords: anti vegf; amd beyond; eyes wet; treatment ... See more keywords
Gene Therapy in Neovascular Age-related Macular Degeneration: Three-Year Follow-up of a Phase 1 Randomized Dose Escalation Trial.
Sign Up to like & getrecommendations! Published in 2017 at "American journal of ophthalmology"
DOI: 10.1016/j.ajo.2017.02.018
Abstract: PURPOSE To assess the safety of rAAV.sFlt-1 subretinal injection in neovascular age-related macular degeneration (wet AMD) over 36 months. DESIGN Phase 1 dose escalation trial. METHODS Eight subjects with advanced, treatment-experienced wet AMD were randomly assigned… read more here.
Keywords: macular degeneration; age related; related macular; wet amd ... See more keywords
The role of complement membrane attack complex in dry and wet AMD - From hypothesis to clinical trials.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental eye research"
DOI: 10.1016/j.exer.2019.05.006
Abstract: Data from human dry and wet age-related macular degeneration (AMD) eyes support the hypothesis that constant 'tickover' of the alternative complement pathway results in chronic deposition of the complement membrane attack complex (MAC) on the… read more here.
Keywords: complement membrane; dry wet; wet amd; membrane attack ... See more keywords
AMD-SD: An Optical Coherence Tomography Image Dataset for wet AMD Lesions Segmentation
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Data"
DOI: 10.1038/s41597-024-03844-6
Abstract: Wet Age-related Macular Degeneration (wet AMD) is a common ophthalmic disease that significantly impacts patients’ vision. Optical coherence tomography (OCT) examination has been widely utilized for diagnosing, treating, and monitoring wet AMD due to its… read more here.
Keywords: optical coherence; dataset; segmentation; wet amd ... See more keywords
Mental Health Consequences of Age-Related Macular Degeneration: Exploring Depression Prevalence and Severity in Wet and Dry Forms.
Sign Up to like & getrecommendations! Published in 2025 at "Clinical gerontologist"
DOI: 10.1080/07317115.2025.2506768
Abstract: ABSTRACT Objectives Age-related macular degeneration (AMD) is a leading cause of vision loss, affecting quality of life. Although AMD is associated with an increased risk of depression, differences between dry and wet forms are not… read more here.
Keywords: age; wet amd; depression; severity ... See more keywords
INCREASED INCIDENCE OF CUTANEOUS KERATINOCYTIC AND MELANOCYTIC MALIGNANCIES IN PATIENTS WITH AGE-RELATED MACULAR DEGENERATION.
Sign Up to like & getrecommendations! Published in 2019 at "Retina"
DOI: 10.1097/iae.0000000000002506
Abstract: PURPOSE The relationship between age-related macular degeneration (AMD) and malignancy, especially cutaneous malignancies, is not well studied. We investigated a possible association between AMD and cutaneous malignancies. METHODS A retrospective, consecutive review of all patients… read more here.
Keywords: wet amd; amd; dry amd; age ... See more keywords
Epithelial-mesenchymal transition-related serum markers ET-1, IL-8 and TGF-β2 are elevated in a Finnish wet age-related macular degeneration cohort.
Sign Up to like & getrecommendations! Published in 2021 at "Acta ophthalmologica"
DOI: 10.1111/aos.15051
Abstract: PURPOSE It has been hypothesized that epithelial-mesenchymal transition (EMT) may occur in the retinal pigment epithelium of advanced stage age-related macular degeneration (AMD). Various serum and plasma growth factors and inflammatory mediators have been linked… read more here.
Keywords: mesenchymal transition; age related; age; epithelial mesenchymal ... See more keywords
Analysis of prognostic and predictive factors in Kuopio wet age‐related macular degeneration cohort
Sign Up to like & getrecommendations! Published in 2024 at "Acta Ophthalmologica"
DOI: 10.1111/aos.15915
Abstract: Aims/Purpose: Aim of this study was to explore factors affecting wet AMD disease progression and identify predictive factors that can estimate the time of intravitreal treatment duration.Methods: This retrospective real‐world study included 421 wet AMD… read more here.
Keywords: age; treatment; irf patients; wet amd ... See more keywords
Systemic immunosuppression and risk of age-related macular degeneration
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0203492
Abstract: A local immune response has been implicated in the pathogenesis of age-related macular degeneration (AMD), but it is unclear if systemic immunosuppressive/immunomodulatory therapy (IMT) protects against the onset and/or progression of AMD. We performed a… read more here.
Keywords: age related; dry amd; wet amd; wet ... See more keywords
Untargeted Metabolomic Study of Patients with Wet Age-Related Macular Degeneration in Aqueous Humor
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Interventions in Aging"
DOI: 10.2147/cia.s475920
Abstract: Purpose The objective of this study was to ascertain metabolic biomarkers and investigate the metabolic alterations associated with aqueous humor (AH) in wet age-related macular degeneration (AMD). Methods AH samples were collected from a total… read more here.
Keywords: related macular; wet age; wet amd; age related ... See more keywords