Elevated YKL-40 serum levels may contribute to wet age-related macular degeneration via the ERK1/2 pathway.
Sign Up to like & getrecommendations! Published in 2021 at "FEBS open bio"
DOI: 10.1002/2211-5463.13223
Abstract: Choroidal neovascularization (CNV) is a key characteristic of wet age-related macular degeneration (AMD) that can lead to severe vision loss in the elderly. Anti-VEGF therapy is currently the premier strategy for wet AMD, but it… read more here.
Keywords: age related; erk1 pathway; wet age; wet amd ... See more keywords
The fate of eyes with wet AMD beyond four years of anti-VEGF therapy
Sign Up to like & getrecommendations! Published in 2018 at "Graefe's Archive for Clinical and Experimental Ophthalmology"
DOI: 10.1007/s00417-018-3907-y
Abstract: PurposeReal-life studies on long-term functional outcome of anti-VEGF treatment for wet age-related macular degeneration (wAMD) are limited. We therefore assessed the 10-year outcomes in our patients.MethodsIn this retrospective study, all patients with newly diagnosed wAMD… read more here.
Keywords: anti vegf; amd beyond; eyes wet; treatment ... See more keywords
Gene Therapy in Neovascular Age-related Macular Degeneration: Three-Year Follow-up of a Phase 1 Randomized Dose Escalation Trial.
Sign Up to like & getrecommendations! Published in 2017 at "American journal of ophthalmology"
DOI: 10.1016/j.ajo.2017.02.018
Abstract: PURPOSE To assess the safety of rAAV.sFlt-1 subretinal injection in neovascular age-related macular degeneration (wet AMD) over 36 months. DESIGN Phase 1 dose escalation trial. METHODS Eight subjects with advanced, treatment-experienced wet AMD were randomly assigned… read more here.
Keywords: macular degeneration; age related; related macular; wet amd ... See more keywords
The role of complement membrane attack complex in dry and wet AMD - From hypothesis to clinical trials.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental eye research"
DOI: 10.1016/j.exer.2019.05.006
Abstract: Data from human dry and wet age-related macular degeneration (AMD) eyes support the hypothesis that constant 'tickover' of the alternative complement pathway results in chronic deposition of the complement membrane attack complex (MAC) on the… read more here.
Keywords: complement membrane; dry wet; wet amd; membrane attack ... See more keywords
INCREASED INCIDENCE OF CUTANEOUS KERATINOCYTIC AND MELANOCYTIC MALIGNANCIES IN PATIENTS WITH AGE-RELATED MACULAR DEGENERATION.
Sign Up to like & getrecommendations! Published in 2019 at "Retina"
DOI: 10.1097/iae.0000000000002506
Abstract: PURPOSE The relationship between age-related macular degeneration (AMD) and malignancy, especially cutaneous malignancies, is not well studied. We investigated a possible association between AMD and cutaneous malignancies. METHODS A retrospective, consecutive review of all patients… read more here.
Keywords: wet amd; amd; dry amd; age ... See more keywords
Epithelial-mesenchymal transition-related serum markers ET-1, IL-8 and TGF-β2 are elevated in a Finnish wet age-related macular degeneration cohort.
Sign Up to like & getrecommendations! Published in 2021 at "Acta ophthalmologica"
DOI: 10.1111/aos.15051
Abstract: PURPOSE It has been hypothesized that epithelial-mesenchymal transition (EMT) may occur in the retinal pigment epithelium of advanced stage age-related macular degeneration (AMD). Various serum and plasma growth factors and inflammatory mediators have been linked… read more here.
Keywords: mesenchymal transition; age related; age; epithelial mesenchymal ... See more keywords
Systemic immunosuppression and risk of age-related macular degeneration
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0203492
Abstract: A local immune response has been implicated in the pathogenesis of age-related macular degeneration (AMD), but it is unclear if systemic immunosuppressive/immunomodulatory therapy (IMT) protects against the onset and/or progression of AMD. We performed a… read more here.
Keywords: age related; dry amd; wet amd; wet ... See more keywords
Dabigatran and Wet AMD, Results From Retinal Pigment Epithelial Cell Monolayers, the Mouse Model of Choroidal Neovascularization, and Patients From the Medicare Data Base
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.896274
Abstract: Background Age-related macular degeneration (AMD), the leading cause of irreversible blindness in elderly Caucasian populations, includes destruction of the blood-retina barrier (BRB) generated by the retinal pigment epithelium-Bruch’s membrane complex (RPE/BrM), and complement activation. Thrombin… read more here.
Keywords: cell; dabigatran; wet amd; choroidal neovascularization ... See more keywords
EFEMP1 Overexpression Contributes to Neovascularization in Age-Related Macular Degeneration
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.547436
Abstract: Purpose: Age-related macular degeneration (AMD) is one of the leading causes of blindness, and choroidal neovascularization (CNV) in AMD can lead to serious visual impairment. Gene expression profiling of human ocular tissues have a great… read more here.
Keywords: age; efemp1; expression; wet amd ... See more keywords
Therapeutic potential of translocator protein ligands for age-related macular degeneration
Sign Up to like & getrecommendations! Published in 2021 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.322460
Abstract: Age-related macular degeneration: Agerelated macular degeneration (AMD) is a retinal degenerative disorder, characterized by the irreversible loss of the central vision during ageing. This chronic, progressive disease has been estimated to currently affect around 196… read more here.
Keywords: macular degeneration; age related; related macular; wet amd ... See more keywords