Wisteria floribunda agglutinin staining for the quantitative assessment of cardiac fibrogenic activity in a mouse model of dilated cardiomyopathy
Sign Up to like & getrecommendations! Published in 2019 at "Laboratory Investigation"
DOI: 10.1038/s41374-019-0279-9
Abstract: Cardiac fibrosis is a typical phenomenon in failing hearts for most cardiac diseases, including dilated cardiomyopathy (DCM), and its specific detection and quantification are crucial for the analysis of cardiac remodeling. Since cardiac fibrosis is… read more here.
Keywords: wfa binding; wfa; floribunda agglutinin; wfa staining ... See more keywords
Withaferin A inhibits lysosomal activity to block autophagic flux and induces apoptosis via energetic impairment in breast cancer cells.
Sign Up to like & getrecommendations! Published in 2019 at "Carcinogenesis"
DOI: 10.1093/carcin/bgz015
Abstract: Withaferin A (WFA), a steroidal lactone, negatively regulates breast cancer growth however, its mechanisms of action remain largely elusive. We found that WFA blocks autophagy flux and lysosomal proteolytic activity in breast cancer cells. WFA… read more here.
Keywords: wfa; breast cancer; cancer cells; cancer ... See more keywords
Withaferin A attenuates ovarian cancer-induced cardiac cachexia
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DOI: 10.1371/journal.pone.0236680
Abstract: Cachexia is a common multifactorial syndrome in the advanced stages of cancer and accounts for approximately 20–30% of all cancer-related fatalities. In addition to the progressive loss of skeletal muscle mass, cancer results in impairments… read more here.
Keywords: cachexia; wfa; ovarian cancer; cardiac cachexia ... See more keywords
Low Concentration of Withaferin a Inhibits Oxidative Stress-Mediated Migration and Invasion in Oral Cancer Cells
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DOI: 10.3390/biom10050777
Abstract: Withaferin A (WFA) has been reported to inhibit cancer cell proliferation based on high cytotoxic concentrations. However, the low cytotoxic effect of WFA in regulating cancer cell migration is rarely investigated. The purpose of this… read more here.
Keywords: wfa; invasion; oral cancer; migration ... See more keywords
Withaferin A inhibits ferroptosis and protects against intracerebral hemorrhage
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.355822
Abstract: Recent studies have indicated that suppressing oxidative stress and ferroptosis can considerably improve the prognosis of intracerebral hemorrhage (ICH). Withaferin A (WFA), a natural compound, exhibits a positive effect on a number of neurological diseases.… read more here.
Keywords: hemorrhage; oxidative stress; wfa; hemin induced ... See more keywords