Activation of GLP-1 receptor signalling alleviates cellular stresses and improves beta cell function in a mouse model of Wolfram syndrome
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DOI: 10.1007/s00125-018-4679-y
Abstract: Aims/hypothesisLoss of functional beta cells results in a gradual progression of insulin insufficiency in Wolfram syndrome caused by recessive WFS1 mutations. However, beta cell dysfunction in Wolfram syndrome has yet to be fully characterised, and… read more here.
Keywords: insulin; beta; wolfram syndrome; beta cell ... See more keywords