Differential whole-genome doubling and homologous recombination deficiencies across breast cancer subtypes from the Taiwanese population
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02597-x
Abstract: Whole-genome doubling (WGD) is an early macro-evolutionary event in tumorigenesis, involving the doubling of an entire chromosome complement. However, its impact on breast cancer subtypes remains unclear. Here, we performed a comprehensive and quantitative analysis… read more here.
Keywords: whole genome; breast; wgd; breast cancer ... See more keywords
A New Hope: A Hermaphroditic Nematode Enables Analysis of a Recent Whole Genome Duplication Event
Sign Up to like & getrecommendations! Published in 2022 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evac169
Abstract: Abstract Whole genome duplication (WGD) is often considered a major driver of evolution that leads to phenotypic novelties. However, the importance of WGD for evolution is still controversial because most documented WGD events occurred anciently… read more here.
Keywords: genome duplication; genome; whole genome; wgd ... See more keywords
A balancing act: how whole-genome doubling and aneuploidy interact in human cancer
Sign Up to like & getrecommendations! Published in 2023 at "Oncotarget"
DOI: 10.18632/oncotarget.28374
Abstract: Aneuploidy, or an abnormal chromosome copy number, is a characteristic feature of cancer, which plays an important role in cancer initiation and progression [1]. Aneuploidy prevalence patterns are tissue-specific, with different chromosomes gained or lost… read more here.
Keywords: genome doubling; whole genome; wgd; cancer ... See more keywords