Differential whole-genome doubling and homologous recombination deficiencies across breast cancer subtypes from the Taiwanese population
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02597-x
Abstract: Whole-genome doubling (WGD) is an early macro-evolutionary event in tumorigenesis, involving the doubling of an entire chromosome complement. However, its impact on breast cancer subtypes remains unclear. Here, we performed a comprehensive and quantitative analysis… read more here.
Keywords: whole genome; breast; wgd; breast cancer ... See more keywords
A New Hope: A Hermaphroditic Nematode Enables Analysis of a Recent Whole Genome Duplication Event
Sign Up to like & getrecommendations! Published in 2022 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evac169
Abstract: Abstract Whole genome duplication (WGD) is often considered a major driver of evolution that leads to phenotypic novelties. However, the importance of WGD for evolution is still controversial because most documented WGD events occurred anciently… read more here.
Keywords: genome duplication; genome; whole genome; wgd ... See more keywords
Abstract 2403: Efficient detection of whole genome duplication: a targeted sequencing approach
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DOI: 10.1158/1538-7445.am2025-2403
Abstract: Whole Genome Duplication (WGD) involves the replication of an organism's entire genome and is linked to increased evolutionary complexity and cancer progression. In tumors, WGD contributes to heterogeneity and therapy resistance, making its identification crucial… read more here.
Keywords: detection; cancer; targeted sequencing; whole genome ... See more keywords
Abstract PR012: Evolutionary dynamics of whole-genome doubling in ovarian cancer
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DOI: 10.1158/1538-7445.canevol23-pr012
Abstract: Chromosomal instability (CIN) is a major driver of tumor progression and treatment resistance in many cancers. CIN is characterized by ongoing chromosome missegregation, segmental aneuploidy and whole-genome doubling (WGD), generating copy number heterogeneity that provides… read more here.
Keywords: cancer; whole genome; cell; ovarian cancer ... See more keywords
A balancing act: how whole-genome doubling and aneuploidy interact in human cancer
Sign Up to like & getrecommendations! Published in 2023 at "Oncotarget"
DOI: 10.18632/oncotarget.28374
Abstract: Aneuploidy, or an abnormal chromosome copy number, is a characteristic feature of cancer, which plays an important role in cancer initiation and progression [1]. Aneuploidy prevalence patterns are tissue-specific, with different chromosomes gained or lost… read more here.
Keywords: genome doubling; whole genome; wgd; cancer ... See more keywords