Whole genome sequencing (WGS) fails to detect antimicrobial resistance (AMR) from heteroresistant subpopulation of Salmonella enterica.
Sign Up to like & getrecommendations! Published in 2020 at "Food microbiology"
DOI: 10.1016/j.fm.2020.103530
Abstract: Due to rapidly falling costs, whole genome sequencing (WGS) is becoming an essential tool in the surveillance of antimicrobial resistance (AMR) in Salmonella enterica. Although there have been many recent works evaluating the accuracy of… read more here.
Keywords: salmonella; whole genome; wgs; resistance ... See more keywords
Next generation microbiological risk assessment: opportunities of whole genome sequencing (WGS) for foodborne pathogen surveillance, source tracking and risk assessment.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of food microbiology"
DOI: 10.1016/j.ijfoodmicro.2017.11.007
Abstract: Whole genome sequencing (WGS) of important foodborne pathogens is a technology under development, but is already employed in routine surveillance by public health agencies and is being increasingly exploited in tracing transmission routes and identifying… read more here.
Keywords: risk; whole genome; wgs; risk assessment ... See more keywords
Microkinetic model for WGS over ionic platinum substituted ceria under r-WGS conditions
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Hydrogen Energy"
DOI: 10.1016/j.ijhydene.2017.03.065
Abstract: Abstract Water Gas Shift reaction (WGS) is limited by the thermodynamic equilibrium constraint at higher temperatures. This is predominantly observed in the reactant feed consisting of reverse WGS (r-WGS) conditions. In order to understand the… read more here.
Keywords: microkinetic model; wgs; wgs conditions; kinetic parameters ... See more keywords
Managing the Unimaginable: Biobank Participant Views on Reconsent for Whole Genome Sequencing of Stored Biospecimens.
Sign Up to like & getrecommendations! Published in 2019 at "Biopreservation and biobanking"
DOI: 10.1089/bio.2018.0077
Abstract: BACKGROUND DNA biobanks frequently obtain broad permissions from sample donors, who agree to allow their biospecimens to be used for a variety of future purposes. A limitation of this approach is that it may not… read more here.
Keywords: whole genome; wgs; biobank; time ... See more keywords
A comprehensive benchmarking of WGS-based deletion structural variant callers
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac221
Abstract: Advances in whole-genome sequencing (WGS) promise to enable the accurate and comprehensive structural variant (SV) discovery. Dissecting SVs from WGS data presents a substantial number of challenges and a plethora of SV detection methods have… read more here.
Keywords: deletion; variant; detection; wgs ... See more keywords
The COMBAT-TB Workbench: Making Powerful Mycobacterium tuberculosis Bioinformatics Accessible
Sign Up to like & getrecommendations! Published in 2022 at "mSphere"
DOI: 10.1128/msphere.00991-21
Abstract: While the reduction in the cost of WGS is making sequencing more affordable in lower- and middle-income countries (LMICs), public health laboratories in these countries seldom have access to bioinformaticians and system support engineers adept… read more here.
Keywords: combat workbench; mycobacterium tuberculosis; wgs; combat ... See more keywords
Comparing Multiple Locus Variable-Number Tandem Repeat Analyses with Whole-Genome Sequencing as Typing Method for Salmonella Enteritidis Surveillance in The Netherlands, January 2019 to March 2020
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01375-22
Abstract: Salmonella is the most frequently reported agent causing foodborne outbreaks and the second most common zoonoses in the European Union. The incidence of the most dominant serotype Enteritidis has increased in recent years. ABSTRACT In… read more here.
Keywords: salmonella; mlva; enteritidis isolates; wgs ... See more keywords
Application of Restriction Site-Associated DNA Sequencing (RAD-Seq) for Copy Number Variation and Triploidy Detection in Human.
Sign Up to like & getrecommendations! Published in 2021 at "Cytogenetic and genome research"
DOI: 10.1159/000518930
Abstract: At present, low-pass whole-genome sequencing (WGS) is frequently used in clinical research and in the screening of copy number variations (CNVs). However, there are still some challenges in the detection of triploids. Restriction site-associated DNA… read more here.
Keywords: seq; detection; wgs; rad seq ... See more keywords
Platelet Phenotype Prediction from Whole Genome Sequencing in 621 Sickle Cell Disease Patients
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-131640
Abstract: Introduction: Patients with sickle cell disease (SCD) are at increased risk of alloimmunization. Platelet refractoriness is a serious known complication and often seen in SCD patients who are heavily transfused and/or in the bone marrow… read more here.
Keywords: wgs; hpa; cell disease; cell ... See more keywords
From cytogenetics to cytogenomics: whole-genome sequencing as a first-line test comprehensively captures the diverse spectrum of disease-causing genetic variation underlying intellectual disability
Sign Up to like & getrecommendations! Published in 2019 at "Genome Medicine"
DOI: 10.1186/s13073-019-0675-1
Abstract: BackgroundSince different types of genetic variants, from single nucleotide variants (SNVs) to large chromosomal rearrangements, underlie intellectual disability, we evaluated the use of whole-genome sequencing (WGS) rather than chromosomal microarray analysis (CMA) as a first-line… read more here.
Keywords: wgs; intellectual disability; cohort; test ... See more keywords
Clinical genomics and precision medicine
Sign Up to like & getrecommendations! Published in 2022 at "Genetics and Molecular Biology"
DOI: 10.1590/1678-4685-gmb-2022-0150
Abstract: Abstract Precision Medicine emerges from the genomic paradigm of health and disease. For precise molecular diagnoses of genetic diseases, we must analyze the Whole Exome (WES) or the Whole Genome (WGS). By not needing exon… read more here.
Keywords: clinical genomics; precision medicine; healthy individuals; wgs ... See more keywords