Association of Regional White Matter Hyperintensities With Longitudinal Alzheimer-Like Pattern of Neurodegeneration in Older Adults
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DOI: 10.1001/jamanetworkopen.2021.25166
Abstract: Key Points Question What is the association of small vessel cerebrovascular disease, operationalized as white matter hyperintensities (WMH), with cortical thinning in a racially and ethnically diverse population of older adults? Findings In this cohort… read more here.
Keywords: cortical thinning; neurodegeneration; older adults; matter hyperintensities ... See more keywords
Association Between Obstructive Sleep Apnea and Brain White Matter Hyperintensities in a Population-Based Cohort in Germany
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DOI: 10.1001/jamanetworkopen.2021.28225
Abstract: Key Points Question Is obstructive sleep apnea (OSA) associated with brain white matter hyperintensities (WMHs)? Findings In this cohort study of 529 participants of the Study of Health in Pomerania-Trend baseline, a statistically significant association… read more here.
Keywords: brain white; brain; obstructive sleep; sleep apnea ... See more keywords
Association of Obstructive Sleep Apnea With White Matter Integrity and Cognitive Performance Over a 4-Year Period in Middle to Late Adulthood
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.22999
Abstract: Key Points Question Is obstructive sleep apnea (OSA) associated with cognition and white matter (WM) integrity over time? Findings In this cohort study of 1110 participants, OSA was associated with impaired cognition and WM integrity… read more here.
Keywords: white matter; sleep apnea; integrity; obstructive sleep ... See more keywords
Imaging of Glial Cell Activation and White Matter Integrity in Brains of Active and Recently Retired National Football League Players
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DOI: 10.1001/jamaneurol.2016.3764
Abstract: Importance Microglia, the resident immune cells of the central nervous system, play an important role in the brain’s response to injury and neurodegenerative processes. It has been proposed that prolonged microglial activation occurs after single… read more here.
Keywords: glial cell; control participants; brain; white matter ... See more keywords
Dynamic Changes in White Matter Hyperintensities in Reversible Cerebral Vasoconstriction Syndrome
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DOI: 10.1001/jamaneurol.2018.1321
Abstract: Importance White matter hyperintense lesions (WMHs) are highly prevalent in patients with reversible cerebral vasoconstriction syndrome (RCVS); however, their characteristics and underlying pathophysiology are unclear. Objective To investigate the spatiotemporal distribution and pathomechanisms of WMHs… read more here.
Keywords: index; patients rcvs; matter; vasoconstriction ... See more keywords
Association of Heritable Cognitive Ability and Psychopathology With White Matter Properties in Children and Adolescents
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2017.4277
Abstract: Importance Many mental disorders emerge during adolescence, which may reflect a cost of the potential for brain plasticity offered during this period. Brain dysconnectivity has been proposed as a common factor across diagnostic categories. Objective… read more here.
Keywords: association; matter properties; brain; psychopathology ... See more keywords
Severe white matter damage in SHANK3 deficiency: a human and translational study
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DOI: 10.1002/acn3.50959
Abstract: Heterozygous SHANK3 mutations or partial deletions of the long arm of chromosome 22, also known as Phelan–McDermid syndrome, result in a syndromic form of the autism spectrum as well as in global developmental delay, intellectual… read more here.
Keywords: deficiency human; shank3 deficiency; severe white; matter damage ... See more keywords
White matter hyperintensities and risk of levodopa‐induced dyskinesia in Parkinson’s disease
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DOI: 10.1002/acn3.50991
Abstract: To investigate whether the burden of white matter hyperintensities (WMHs) is associated with the risk of developing levodopa‐induced dyskinesia (LID) in Parkinson’s disease (PD). read more here.
Keywords: levodopa induced; parkinson disease; induced dyskinesia; matter hyperintensities ... See more keywords
White matter hyperintensities: a marker for apathy in Parkinson’s disease without dementia?
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DOI: 10.1002/acn3.51159
Abstract: The objective of this study was to assess the relationship between white matter hyperintensities (WMH) and the occurrence and progression of apathy in Parkinson’s disease (PD). read more here.
Keywords: parkinson disease; apathy parkinson; matter hyperintensities; white matter ... See more keywords
White matter microstructures in Parkinson's disease with and without impulse control behaviors
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DOI: 10.1002/acn3.51504
Abstract: Impulse control behaviors (ICBs) in Parkinson's disease (PD) are thought to be caused by an overdose of dopaminergic therapy in the relatively spared ventral striatum, or by hypersensitivity of this region to dopamine. Alterations in… read more here.
Keywords: impulse control; white matter; parkinson disease; control behaviors ... See more keywords
Altered brain white matter structural motor network in spinocerebellar ataxia type 3
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DOI: 10.1002/acn3.51713
Abstract: Spinocerebellar ataxia type 3 is a disorder within the brain network. However, the relationship between the brain network and disease severity is still unclear. This study aims to investigate changes in the white matter (WM)… read more here.
Keywords: network; white matter; brain; ataxia type ... See more keywords