Whole organism to tissue concentration ratios derived from an Australian tropical dataset.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of environmental radioactivity"
DOI: 10.1016/j.jenvrad.2018.03.002
Abstract: Whole organism to tissue concentration ratios (CRwo-tissue) were derived for six wildlife groups (freshwater birds, freshwater bivalves, freshwater fishes, freshwater reptiles, freshwater vascular plants and terrestrial mammals). The wildlife groups and data represented species common… read more here.
Keywords: organism tissue; concentration ratios; tissue; tissue concentration ... See more keywords
II. Species sensitivity distributions based on biomarkers and whole organism responses for integrated impact and risk assessment criteria.
Sign Up to like & getrecommendations! Published in 2017 at "Marine environmental research"
DOI: 10.1016/j.marenvres.2016.12.003
Abstract: The aim of this paper is to bridge gaps between biomarker and whole organism responses related to oil based offshore discharges. These biomarker bridges will facilitate acceptance criteria for biomarker data linked to environmental risk… read more here.
Keywords: risk assessment; risk; whole organism; organism responses ... See more keywords
Development of a Whole Organism Platform for Phenotype-Based Analysis of IGF1R-PI3K-Akt-Tor Action
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-01687-3
Abstract: Aberrant regulation of the insulin-like growth factor (IGF)/insulin (IIS)-PI3K-AKT-TOR signaling pathway is linked to major human diseases, and key components of this pathway are targets for therapeutic intervention. Current assays are molecular target- or cell… read more here.
Keywords: akt tor; platform; whole organism; pi3k akt ... See more keywords
Introduction to the Symposium: Integrative Life-History of Whole-Organism Performance.
Sign Up to like & getrecommendations! Published in 2017 at "Integrative and comparative biology"
DOI: 10.1093/icb/icx084
Abstract: SYNOPSIS A strong case can be made for whole-organism performance traits (i.e., dynamic, ecologically relevant traits whose expression is shaped by underlying morphological factors) as being the ultimate integrative traits. This is not only because… read more here.
Keywords: life history; whole organism; performance; organism performance ... See more keywords
Chemical Attenuation in the Development of a Whole-Organism Malaria Vaccine
Sign Up to like & getrecommendations! Published in 2017 at "Infection and Immunity"
DOI: 10.1128/iai.00062-17
Abstract: ABSTRACT Malaria vaccine development has been dominated by the subunit approach; however, many subunit vaccine candidates have had limited efficacy in settings of malaria endemicity. As our search for an efficacious malaria vaccine continues, the… read more here.
Keywords: chemical attenuation; development whole; whole organism; vaccine ... See more keywords
Zebrafish: An emerging whole-organism screening tool in safety pharmacology
Sign Up to like & getrecommendations! Published in 2020 at "Indian Journal of Pharmacology"
DOI: 10.4103/ijp.ijp_482_19
Abstract: During the last two decades, the development in drug discovery is slackening due to drug withdrawal from the market or reported to have postmarket safety events. The vital organ toxicities, especially cardiotoxicity, hepatotoxicity, pulmonary toxicity,… read more here.
Keywords: whole organism; screening model; drug; organism screening ... See more keywords
Whole-organism 3D quantitative characterization of zebrafish melanin by silver deposition micro-CT
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.68920
Abstract: We previously described X-ray histotomography, a high-resolution, non-destructive form of X-ray microtomography (micro-CT) imaging customized for three-dimensional (3D), digital histology, allowing quantitative, volumetric tissue and organismal phenotyping (Ding et al., 2019). Here, we have combined… read more here.
Keywords: whole organism; silver; melanin; quantitative characterization ... See more keywords