Multiple myeloma driving factor WHSC1 is a transcription target of oncogene HMGA2 that facilitates colon cancer proliferation and metastasis.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.06.034
Abstract: Colon cancer is a common human cancer worldwide. The survival rate of late staged or metastatic colon cancer patients remains low even though the effectiveness of treatment in colon cancer has greatly improved. Research on… read more here.
Keywords: whsc1; multiple myeloma; cancer proliferation; colon cancer ... See more keywords
Circular RNA WHSC1 exerts oncogenic properties by regulating miR‐7/TAB2 in lung cancer
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16925
Abstract: Circular RNA is a newly discovered member of non‐coding RNA (ncRNA) and regulates the target gene by acting as a micro‐RNA sponge. It plays vital roles in various diseases. However, the functions of circular RNA… read more here.
Keywords: whsc1; mir; circ whsc1; lung cancer ... See more keywords
WHSC1 is involved in DNA damage, cellular senescence and immune response in hepatocellular carcinoma progression
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17743
Abstract: Wolf–Hirschhorn syndrome candidate 1 (WHSC1) is a transcriptional regulatory protein that encodes a histone methyltransferase to control H3K36me2 modification. WHSC1 was upregulated and associated with poor prognosis in HCC. The elevated WHSC1 likely due to… read more here.
Keywords: involved dna; senescence immune; dna damage; whsc1 ... See more keywords
WHSC1/NSD2 regulates immune infiltration in prostate cancer
Sign Up to like & getrecommendations! Published in 2021 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2020-001374
Abstract: Background Immunotherapy in prostate cancer (PCa) lags behind the progresses obtained in other cancer types partially because of its limited immune infiltration. Tumor-resident immune cells have been detected in the prostate, but the regulatory mechanisms… read more here.
Keywords: whsc1; prostate cancer; immune infiltration; cancer ... See more keywords