Genome-wide Association of Endophenotypes for Schizophrenia From the Consortium on the Genetics of Schizophrenia (COGS) Study.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2019.2850
Abstract: Importance The Consortium on the Genetics of Schizophrenia (COGS) uses quantitative neurophysiological and neurocognitive endophenotypes with demonstrated deficits in schizophrenia as a platform from which to explore the underlying neural circuitry and genetic architecture. Many… read more here.
Keywords: genome wide; genetics schizophrenia; genetics; association ... See more keywords
Association of OPRM1 Functional Coding Variant With Opioid Use Disorder: A Genome-Wide Association Study.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2020.1206
Abstract: Importance With the current opioid crisis, it is important to improve understanding of the biological mechanisms of opioid use disorder (OUD). Objectives To detect genetic risk variants for OUD and determine genetic correlations and causal… read more here.
Keywords: genome wide; association; association study; american individuals ... See more keywords
Epigenome‐wide association study, meta‐analysis, and multiscore profiling of whole blood in Parkinson's disease
Sign Up to like & getrecommendations! Published in 2025 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.52292
Abstract: An increasing body of evidence indicates altered DNA methylation in Parkinson's disease, yet the reproducibility and utility of such methylation changes are largely unexplored. We aimed to further elucidate the role of dysregulated DNA methylation… read more here.
Keywords: epigenome wide; methylation; wide association; parkinson ... See more keywords
Metabolome-Based Genome-Wide Association Study of Duck Meat Leads to Novel Genetic and Biochemical Insights.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300148
Abstract: Meat is among the most consumed foods worldwide and has a unique flavor and high nutrient density in the human diet. However, the genetic and biochemical bases of meat nutrition and flavor are poorly understood.… read more here.
Keywords: metabolome based; based genome; genome wide; wide association ... See more keywords
Leveraging Random Effects in Cistrome‐Wide Association Studies for Decoding the Genetic Determinants of Prostate Cancer
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202400815
Abstract: Cistrome‐wide association studies (CWAS) are pivotal for identifying genetic determinants of diseases by correlating genetically regulated cistrome states with phenotypes. Traditional CWAS typically develops a model based on cistrome and genotype data to associate predicted… read more here.
Keywords: prostate cancer; wide association; cistrome wide; cwas ... See more keywords
Genome‐wide association studies reveal shared genetic haplotypes of autoimmune rheumatic and endocrine diseases with psychiatric disorders
Sign Up to like & getrecommendations! Published in 2023 at "Brain and Behavior"
DOI: 10.1002/brb3.2955
Abstract: Several studies have shown that autoimmune diseases are associated with psychiatric diseases like depression and psychosis. Genetic evidence supports this association. The aim of this study was to investigate if genetic variants predisposing to autoimmune… read more here.
Keywords: psychiatric disorders; genome wide; wide association; diseases psychiatric ... See more keywords
Transcriptome‐wide association study identifies multiple genes and pathways associated with pancreatic cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1836
Abstract: To identify novel candidate genes for pancreatic cancer. read more here.
Keywords: study identifies; pancreatic cancer; transcriptome wide; cancer ... See more keywords
A Transcriptome‐Wide Association Study Identifies Candidate Susceptibility Loci and Genes for Lung Cancer Risk
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Medicine"
DOI: 10.1002/cam4.71301
Abstract: Genome‐wide association studies (GWAS) have identified over 80 susceptibility loci for lung cancer risk. However, the genes underlying these associations remain largely unknown. read more here.
Keywords: cancer risk; cancer; lung cancer; susceptibility loci ... See more keywords
Laboratory‐wide association study of survival with prostate cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer"
DOI: 10.1002/cncr.33341
Abstract: Estimates of overall patient health are essential to inform treatment decisions for patients diagnosed with cancer. The authors applied XWAS methods, herein referred to as “laboratory‐wide association study (LWAS)”, to evaluate associations between routinely collected… read more here.
Keywords: prostate cancer; cancer; association study; laboratory wide ... See more keywords
Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome‐Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.1359
Abstract: Anastrozole is a widely prescribed aromatase inhibitor for the therapy of estrogen receptor positive (ER+) breast cancer. We performed a genome‐wide association study (GWAS) for plasma anastrozole concentrations in 687 postmenopausal women with ER+ breast… read more here.
Keywords: genome wide; slc38a7; aromatase inhibitor; epistatic interaction ... See more keywords
DrugWAS: Drug‐wide Association Studies for COVID‐19 Drug Repurposing
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2376
Abstract: This study aimed to systematically investigate if any of the available drugs in the electronic health record (EHR) can be repurposed as potential treatment for coronavirus disease 2019 (COVID‐19). Based on a retrospective cohort analysis… read more here.
Keywords: association studies; drug wide; drug; covid ... See more keywords