Genome-wide Association of Endophenotypes for Schizophrenia From the Consortium on the Genetics of Schizophrenia (COGS) Study.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2019.2850
Abstract: Importance The Consortium on the Genetics of Schizophrenia (COGS) uses quantitative neurophysiological and neurocognitive endophenotypes with demonstrated deficits in schizophrenia as a platform from which to explore the underlying neural circuitry and genetic architecture. Many… read more here.
Keywords: genome wide; genetics schizophrenia; genetics; association ... See more keywords
Association of OPRM1 Functional Coding Variant With Opioid Use Disorder: A Genome-Wide Association Study.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2020.1206
Abstract: Importance With the current opioid crisis, it is important to improve understanding of the biological mechanisms of opioid use disorder (OUD). Objectives To detect genetic risk variants for OUD and determine genetic correlations and causal… read more here.
Keywords: genome wide; association; association study; american individuals ... See more keywords
Metabolome-Based Genome-Wide Association Study of Duck Meat Leads to Novel Genetic and Biochemical Insights.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300148
Abstract: Meat is among the most consumed foods worldwide and has a unique flavor and high nutrient density in the human diet. However, the genetic and biochemical bases of meat nutrition and flavor are poorly understood.… read more here.
Keywords: metabolome based; based genome; genome wide; wide association ... See more keywords
Genome‐wide association studies reveal shared genetic haplotypes of autoimmune rheumatic and endocrine diseases with psychiatric disorders
Sign Up to like & getrecommendations! Published in 2023 at "Brain and Behavior"
DOI: 10.1002/brb3.2955
Abstract: Several studies have shown that autoimmune diseases are associated with psychiatric diseases like depression and psychosis. Genetic evidence supports this association. The aim of this study was to investigate if genetic variants predisposing to autoimmune… read more here.
Keywords: psychiatric disorders; genome wide; wide association; diseases psychiatric ... See more keywords
Transcriptome‐wide association study identifies multiple genes and pathways associated with pancreatic cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1836
Abstract: To identify novel candidate genes for pancreatic cancer. read more here.
Keywords: study identifies; pancreatic cancer; transcriptome wide; cancer ... See more keywords
Laboratory‐wide association study of survival with prostate cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer"
DOI: 10.1002/cncr.33341
Abstract: Estimates of overall patient health are essential to inform treatment decisions for patients diagnosed with cancer. The authors applied XWAS methods, herein referred to as “laboratory‐wide association study (LWAS)”, to evaluate associations between routinely collected… read more here.
Keywords: prostate cancer; cancer; association study; laboratory wide ... See more keywords
Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome‐Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.1359
Abstract: Anastrozole is a widely prescribed aromatase inhibitor for the therapy of estrogen receptor positive (ER+) breast cancer. We performed a genome‐wide association study (GWAS) for plasma anastrozole concentrations in 687 postmenopausal women with ER+ breast… read more here.
Keywords: genome wide; slc38a7; aromatase inhibitor; epistatic interaction ... See more keywords
DrugWAS: Drug‐wide Association Studies for COVID‐19 Drug Repurposing
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2376
Abstract: This study aimed to systematically investigate if any of the available drugs in the electronic health record (EHR) can be repurposed as potential treatment for coronavirus disease 2019 (COVID‐19). Based on a retrospective cohort analysis… read more here.
Keywords: association studies; drug wide; drug; covid ... See more keywords
Joint genotype‐ and ancestry‐based genome‐wide association studies in admixed populations
Sign Up to like & getrecommendations! Published in 2017 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22056
Abstract: In genome‐wide association studies (GWAS) genetic loci that influence complex traits are localized by inspecting associations between genotypes of genetic markers and the values of the trait of interest. On the other hand, admixture mapping,… read more here.
Keywords: genome wide; association studies; genotype ancestry; ancestry ... See more keywords
Estimation of a significance threshold for epigenome‐wide association studies
Sign Up to like & getrecommendations! Published in 2018 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22086
Abstract: Epigenome‐wide association studies (EWAS) are designed to characterise population‐level epigenetic differences across the genome and link them to disease. Most commonly, they assess DNA‐methylation status at cytosine‐guanine dinucleotide (CpG) sites, using platforms such as the… read more here.
Keywords: association studies; significance threshold; significance; epigenome wide ... See more keywords
Effect of case and control definitions on genome-wide association study (GWAS) findings.
Sign Up to like & getrecommendations! Published in 2023 at "Genetic epidemiology"
DOI: 10.1002/gepi.22523
Abstract: Genome-wide association studies (GWAS) have significantly advanced our understanding of the genetic underpinnings of diseases, but case and control cohort definitions for a given disease can vary between different published studies. For example, two GWAS… read more here.
Keywords: data sources; genome wide; wide association; case ... See more keywords