Genome-Wide Codon Reprogramming Enables a Multifactorially Attenuated Influenza Vaccine with Broad Cross-Protection.
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DOI: 10.1002/advs.202516448
Abstract: Live attenuated influenza vaccines (LAIVs) can elicit broad immunity, but rational attenuation strategies are limited. PR8rp, a prototype influenza A virus with five segments extensively reprogrammed to use the least-preferred synonymous codons is generated, introducing… read more here.
Keywords: protection; attenuated influenza; genome wide; wide codon ... See more keywords