Millisecond dynamics of BTK reveal kinome-wide conformational plasticity within the apo kinase domain
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DOI: 10.1038/s41598-017-10697-0
Abstract: Bruton tyrosine kinase (BTK) is a key enzyme in B-cell development whose improper regulation causes severe immunodeficiency diseases. Design of selective BTK therapeutics would benefit from improved, in-silico structural modeling of the kinase’s solution ensemble.… read more here.
Keywords: wide conformational; kinase; kinase domain; millisecond ... See more keywords