Genome-wide functional association networks: background, data & state-of-the-art resources
Sign Up to like & getrecommendations! Published in 2020 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbz064
Abstract: Abstract The vast amount of experimental data from recent advances in the field of high-throughput biology begs for integration into more complex data structures such as genome-wide functional association networks. Such networks have been used… read more here.
Keywords: genome wide; field; association networks; functional association ... See more keywords
Genome-wide functional analyses of plant coiled–coil NLR-type pathogen receptors reveal essential roles of their N-terminal domain in oligomerization, networking, and immunity
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DOI: 10.1371/journal.pbio.2005821
Abstract: The ability to induce a defense response after pathogen attack is a critical feature of the immune system of any organism. Nucleotide-binding leucine-rich repeat receptors (NLRs) are key players in this process and perceive the… read more here.
Keywords: genome wide; pathogen; plant; functional analyses ... See more keywords
Genome-wide functional analysis reveals key roles for kinesins in the mammalian and mosquito stages of the malaria parasite life cycle
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DOI: 10.1371/journal.pbio.3001704
Abstract: Kinesins are microtubule-based motors important in cell division, motility, polarity, and intracellular transport in many eukaryotes. However, they are poorly studied in the divergent eukaryotic pathogens- Plasmodium spp., the causative agents of malaria, which manifest… read more here.
Keywords: mammalian mosquito; genome wide; wide functional; mosquito ... See more keywords
A genome-wide functional genomics approach uncovers genetic determinants of immune phenotypes in type 1 diabetes
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DOI: 10.7554/elife.73709
Abstract: Background: The large inter-individual variability in immune-cell composition and function determines immune responses in general and susceptibility o immune-mediated diseases in particular. While much has been learned about the genetic variants relevant for type 1… read more here.
Keywords: genetic determinants; genome wide; wide functional; type diabetes ... See more keywords