Genome‐wide meta‐analysis identifies susceptibility loci for autoimmune hepatitis type 1
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32417
Abstract: Autoimmune hepatitis (AIH) is a rare and chronic autoimmune liver disease. While genetic factors are believed to play a crucial role in the etiopathogenesis of AIH, our understanding of these genetic risk factors is still… read more here.
Keywords: wide meta; autoimmune hepatitis; susceptibility loci; genome wide ... See more keywords
Genome-wide meta-analysis identifies novel loci of plaque burden in carotid artery.
Sign Up to like & getrecommendations! Published in 2017 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2017.02.018
Abstract: BACKGROUND AND AIMS Carotid artery plaque is an established marker of subclinical atherosclerosis and common patho-mechanisms with coronary artery disease (CAD) are hypothesized. We aimed to identify genetic variants associated with carotid plaque and to… read more here.
Keywords: plaque; genome wide; carotid artery; wide meta ... See more keywords
Genome-wide meta-analysis, fine-mapping, and integrative prioritization implicate new Alzheimer’s disease risk genes
Sign Up to like & getrecommendations! Published in 2021 at "Nature genetics"
DOI: 10.1038/s41588-020-00776-w
Abstract: Genome-wide association studies (GWAS) have discovered numerous genomic loci associated with Alzheimer’s disease (AD), yet the causal genes and variants remain incompletely identified. We performed an updated genome-wide AD meta-analysis, which identified 37 risk loci,… read more here.
Keywords: genome wide; risk; alzheimer disease; wide meta ... See more keywords
Genome‐wide meta‐analysis and replication studies in multiple ethnicities identify novel adolescent idiopathic scoliosis susceptibility loci
Sign Up to like & getrecommendations! Published in 2018 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy306
Abstract: &NA; Adolescent idiopathic scoliosis (AIS) is the most common musculoskeletal disorder of childhood development. The genetic architecture of AIS is complex, and the great majority of risk factors are undiscovered. To identify new AIS susceptibility… read more here.
Keywords: genome wide; idiopathic scoliosis; analysis; adolescent idiopathic ... See more keywords
OP0048 GENOME-WIDE META-ANALYSIS REVEALED MULTIPLE NOVEL LOCI ASSOCIATED WITH SERUM URIC ACIDLEVELS IN JAPANESE
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.4039
Abstract: Background Uric acid is an end metabolite of purines which is produced predominantly in the liver and is excreted by the kidneys and the intestine. Genes for urate transporters and proteins associated with cell metabolism… read more here.
Keywords: loci; genome wide; analysis; wide meta ... See more keywords
Comment on Dawed et al. Genome-Wide Meta-Analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas. Diabetes Care 2021;44:2673–2682
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes Care"
DOI: 10.2337/dc21-2428
Abstract: We read with interest the article by Dawed et al. (1) reporting genetic variants associated with sulfonylurea response in a genome-wide meta-analysis of White Europeans. The C allele of rs10770791 in the intronic region of… read more here.
Keywords: variants associated; genetic variants; sulfonylurea response; genome wide ... See more keywords
Genome-Wide Meta-Analysis Identifies Two Novel Risk Loci for Epilepsy
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.722592
Abstract: Epilepsy (affects about 70 million people worldwide) is one of the most prevalent brain disorders and imposes a huge economic burden on society. Epilepsy has a strong genetic component. In this study, we perform the… read more here.
Keywords: epilepsy; genome wide; risk; wide meta ... See more keywords