Genome-wide synthetic lethal CRISPR screen identifies FIS1 as a genetic interactor of ALS-linked C9ORF72
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DOI: 10.1016/j.brainres.2019.146601
Abstract: Mutations in the C9ORF72 gene are the most common cause of amyotrophic lateral sclerosis (ALS). Both toxic gain of function and loss of function pathogenic mechanisms have been proposed. Accruing evidence from mouse knockout studies… read more here.
Keywords: genome wide; c9orf72; wide synthetic; lethal crispr ... See more keywords