Genetically encoded stealth nanoparticles of a zwitterionic polypeptide-paclitaxel conjugate have a wider therapeutic window than Abraxane in multiple tumor models.
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DOI: 10.1021/acs.nanolett.9b05094
Abstract: Small-molecule therapeutics demonstrate sub-optimal pharmacokinetics and bioavailability due to their hydrophobicity and size. One way to overcome these limitations-and improve their efficacy-is to use "stealth" macromolecular carriers that evade uptake by the reticuloendothelial system. Although… read more here.
Keywords: therapeutic window; stealth; window abraxane; wider therapeutic ... See more keywords