Continuation of Bevacizumab vs Cetuximab Plus Chemotherapy After First Progression in KRAS Wild-Type Metastatic Colorectal Cancer: The UNICANCER PRODIGE18 Randomized Clinical Trial
Sign Up to like & getrecommendations! Published in 2019 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2018.4465
Abstract: Importance Second-line treatment with chemotherapy plus bevacizumab or cetuximab is a valid option for metastatic colorectal cancer. Objective To evaluate the progression-free survival (PFS) rate at 4 months with chemotherapy plus bevacizumab vs cetuximab for… read more here.
Keywords: chemotherapy; metastatic colorectal; bevacizumab; colorectal cancer ... See more keywords
Alpelisib Plus Fulvestrant in PIK3CA-Altered and PIK3CA-Wild-Type Estrogen Receptor–Positive Advanced Breast Cancer: A Phase 1b Clinical Trial
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2018.4475
Abstract: Importance The phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in patients with estrogen receptor–positive (ER+), endocrine therapy–resistant breast cancers. Objective To assess the maximum tolerated dose (MTD), safety, and activity of alpelisib, an oral, PI3K&agr;-specific… read more here.
Keywords: phase; plus fulvestrant; pik3ca altered; wild type ... See more keywords
Modulation of O2 reduction in Saccharomyces cerevisiae mitochondria
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12918
Abstract: Respiratory supercomplex factor (Rcf) 1 is a membrane‐bound protein that modulates the activity of cytochrome c oxidase (CytcO) in Saccharomyces cerevisiae mitochondria. To investigate this regulatory mechanism, we studied the interactions of CytcO with potassium… read more here.
Keywords: reduction; cerevisiae mitochondria; saccharomyces cerevisiae; rcf1 ... See more keywords
Gibberellins are involved in effect of near-null magnetic field on Arabidopsis flowering.
Sign Up to like & getrecommendations! Published in 2017 at "Bioelectromagnetics"
DOI: 10.1002/bem.22004
Abstract: We previously found that flowering of Arabidopsis was suppressed by near-null magnetic field, which was related to the modification of cryptochrome. To disclose the physiological mechanism of this effect, we detected gibberellin (GA) levels and… read more here.
Keywords: field; near null; null magnetic; magnetic field ... See more keywords
High‐level production of wild‐type and oxidation‐resistant recombinant alpha‐1‐antitrypsin in glycoengineered CHO cells
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28129
Abstract: Alpha‐1‐antitrypsin (A1AT) is a serine protease inhibitor which blocks the activity of serum proteases including neutrophil elastase to protect the lungs. Its deficiency is known to increase the risk of pulmonary emphysema as well as… read more here.
Keywords: oxidation; alpha antitrypsin; a1at; cho cells ... See more keywords
Preliminary Structural Data Revealed That the SARS‐CoV‐2 B.1.617 Variant's RBD Binds to ACE2 Receptor Stronger Than the Wild Type to Enhance the Infectivity
Sign Up to like & getrecommendations! Published in 2021 at "Chembiochem"
DOI: 10.1002/cbic.202100191
Abstract: The evolution of new SARS‐CoV‐2 variants around the globe has made the COVID‐19 pandemic more worrisome, further pressuring the health care system and immunity. Novel variations that are unique to the receptor‐binding motif (RBM) of… read more here.
Keywords: 617 variant; rbd; receptor; sars cov ... See more keywords
Scalable and Chromatography-Free Synthesis of Efflux Pump Inhibitor Phenylalanine Arginine β-Naphthylamide for its Validation in Wild-Type Bacterial Strains.
Sign Up to like & getrecommendations! Published in 2023 at "ChemMedChem"
DOI: 10.1002/cmdc.202300128
Abstract: Phenylalanine arginine β-naphthylamine, or PAβN, is a C-terminus capped dipeptide discovered as an RND-type efflux pump inhibitor (EPI) in 1999. Since then, PAβN has become a standard tool compound in EPI research and development. Despite… read more here.
Keywords: synthesis; efflux pump; phenylalanine arginine; type bacterial ... See more keywords
Features of atrial fibrillation in wild‐type transthyretin cardiac amyloidosis: a systematic review and clinical experience
Sign Up to like & getrecommendations! Published in 2018 at "ESC Heart Failure"
DOI: 10.1002/ehf2.12308
Abstract: Wild‐type transthyretin (ATTRwt) cardiac amyloidosis has emerged as an important cause of heart failure in the elderly. Atrial fibrillation (AF) commonly affects older adults with heart failure and is associated with reduced survival, but its… read more here.
Keywords: atrial fibrillation; wild type; cardiac amyloidosis; type transthyretin ... See more keywords
A simple staging system using biomarkers for wild‐type transthyretin amyloid cardiomyopathy in Japan
Sign Up to like & getrecommendations! Published in 2022 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13847
Abstract: It has been reported that a staging system combining N‐terminal pro‐B‐type natriuretic peptide and high‐sensitivity troponin T (hs‐cTnT) or estimated glomerular filtration rate (eGFR) is useful in patients with wild‐type transthyretin amyloid cardiomyopathy (ATTRwt‐CM). However,… read more here.
Keywords: system; staging system; type transthyretin; amyloid cardiomyopathy ... See more keywords
Suspicion, screening, and diagnosis of wild‐type transthyretin amyloid cardiomyopathy: a systematic literature review
Sign Up to like & getrecommendations! Published in 2022 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13884
Abstract: Wild‐type transthyretin amyloid cardiomyopathy (ATTRwt CM) is a more common disease than previously thought. Awareness of ATTRwt CM and its diagnosis has been challenged by its unspecific and widely distributed clinical manifestations and traditionally invasive… read more here.
Keywords: amyloid cardiomyopathy; type transthyretin; transthyretin amyloid; diagnosis ... See more keywords
Diagnostic Pathways to Wild-Type Transthyretin Amyloid Cardiomyopathy: a Multicenter Network Study.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of heart failure"
DOI: 10.1002/ejhf.2823
Abstract: BACKGROUND Epidemiology of wild-type transthyretin cardiac amyloidosis (ATTRwt-CA) remains poorly defined. A better characterization of pathways leading to ATTRwt-CA diagnosis is of key importance, and potentially informative of disease course and prognosis. OBJECTIVES To describe… read more here.
Keywords: type transthyretin; diagnosis; pathway; study ... See more keywords