von Willebrand factor propeptide missense variants affect anterograde transport to Golgi resulting in ER retention
Sign Up to like & getrecommendations! Published in 2021 at "Human Mutation"
DOI: 10.1002/humu.24204
Abstract: von Willebrand disease (VWD), the most prevalent congenital bleeding disorder, arises from a deficiency in von Willebrand factor (VWF), which has crucial roles in hemostasis. The present study investigated functional consequences and underlying pathomolecular mechanisms… read more here.
Keywords: missense variants; von willebrand; willebrand factor;
Feedback modulation of endothelial cells promotes epithelialâmesenchymal transition and metastasis of osteosarcoma cells by Von Willebrand Factor release
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28875
Abstract: Endothelial cells (ECs), as a tumor niche cell, generate and secrete Von Willebrand factor (VWF) that is linked to osteosarcoma (OS) progression. However, the role and regulatory mechanisms of VWF that underpin OS progression remain… read more here.
Keywords: mesenchymal transition; epithelial mesenchymal; endothelial cells; von willebrand ... See more keywords
Thrombosis and von Willebrand Factor.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/5584_2016_122
Abstract: One of the key players in both hemostasis and thrombosis is von Willebrand factor (vWF), which demonstrates a duality between these two processes. Thrombus is structured by numerous elements, including endothelial cells, platelets, plasma proteins… read more here.
Keywords: vwf; thrombosis von; von willebrand; willebrand factor ... See more keywords
Laboratory Testing for von Willebrand Factor: Factor VIII Binding (for 2N VWD).
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7196-1_34
Abstract: Von Willebrand disease (VWD) is reportedly the most common inherited bleeding disorder and can also arise as an acquired syndrome (AVWS). These disorders develop due to defects and/or deficiency of the plasma protein von Willebrand… read more here.
Keywords: laboratory testing; von willebrand; willebrand factor; factor ... See more keywords
Clinical role of von Willebrand factor in acute ischemic stroke
Sign Up to like & getrecommendations! Published in 2017 at "Wiener klinische Wochenschrift"
DOI: 10.1007/s00508-017-1200-4
Abstract: SummaryBackgroundAn elevated level of von Willebrand factor (VWF) is associated with an increased risk for coronary heart disease and ischemic stroke. The objective of the study was to determine whether the level of VWF is… read more here.
Keywords: ischemic stroke; acute ischemic; von willebrand; willebrand factor ... See more keywords
Biophysical Mechanisms of Von Willebrand Factor-Collagen Interactions
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2439
Abstract: Von Willebrand factor (VWF) is a multimeric plasma glycoprotein that mediates platelet adhesion onto bleeding blood vessels by binding to both sub-endothelial collagen and platelets. VWF-collagen interactions are capable of resisting the substantial force imposed… read more here.
Keywords: collagen; collagen interactions; von willebrand; willebrand factor ... See more keywords
Mechano-Induced Unfolding of Von Willebrand Factor: A Clinical Example of Protein Destabilization
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2653
Abstract: Protein stability can be quantified, in experiments or simulations, by monitoring changes in free energy induced by single amino-acid mutations relative to changes imposed by the same mutation in a reference unfolded peptide. We here… read more here.
Keywords: protein; cleavage; induced unfolding; destabilization ... See more keywords
Internal Tensile Force and A2 Domain Unfolding of von Willebrand Factor Multimers in Shear Flow.
Sign Up to like & getrecommendations! Published in 2018 at "Biophysical journal"
DOI: 10.1016/j.bpj.2018.09.001
Abstract: Using Brownian molecular dynamics simulations, we examine the internal dynamics and biomechanical response of von Willebrand factor (vWF) multimers subject to shear flow. The coarse grain multimer description employed here is based on a monomer… read more here.
Keywords: shear flow; force; von willebrand; willebrand factor ... See more keywords
Assembly Mechanism of Mucin and von Willebrand Factor Polymers
Sign Up to like & getrecommendations! Published in 2020 at "Cell"
DOI: 10.1016/j.cell.2020.09.021
Abstract: Summary The respiratory and intestinal tracts are exposed to physical and biological hazards accompanying the intake of air and food. Likewise, the vasculature is threatened by inflammation and trauma. Mucin glycoproteins and the related von… read more here.
Keywords: assembly mechanism; von willebrand; mucin; willebrand factor ... See more keywords
Profile of von Willebrand factor antigen and von Willebrand factor propeptide in an overall TIA and ischaemic stroke population and amongst subtypes
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2017.02.045
Abstract: INTRODUCTION Von Willebrand factor propeptide (VWF:Ag II) is proposed to be a more sensitive marker of acute endothelial activation than von Willebrand factor antigen (VWF:Ag). Simultaneous data on VWF:Ag and VWF:Ag II profiles are very… read more here.
Keywords: vwf levels; vwf; von willebrand; willebrand factor ... See more keywords
Effects of hydrophobicity, tethering and size on flow-induced activation of von Willebrand factor multimers.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2019.110050
Abstract: Von Willebrand factor (VWF) is a multimeric protein of blood plasma that mediates platelet adhesion to injury under strong hemodynamic flows in arterias and microvasvulature. We present a 3D coarse-grained computer model of VWF multimers… read more here.
Keywords: vwf multimers; von willebrand; activation; flow induced ... See more keywords