Abstract 2689: Targeting the proteasome pathway in dactinomycin resistant Wilms tumors
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DOI: 10.1158/1538-7445.am2023-2689
Abstract: Nephroblastomas or Wilms tumors are the most common pediatric renal cancer. Across all cases, the 5-year overall survival is over 90%. This is largely in part due to brute-force, chemotherapy regimens such as dactinomycin (actD)… read more here.
Keywords: targeting proteasome; wilms; dactinomycin; tumor ... See more keywords
Characterization of Continuous Transcriptional Heterogeneity in High-Risk Blastemal-Type Wilms’ Tumors Using Unsupervised Machine Learning
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DOI: 10.3390/ijms24043532
Abstract: Wilms’ tumors are pediatric malignancies that are thought to arise from faulty kidney development. They contain a wide range of poorly differentiated cell states resembling various distorted developmental stages of the fetal kidney, and as… read more here.
Keywords: heterogeneity high; blastemal type; risk blastemal; high risk ... See more keywords