Characteristics and outcomes of preoperatively treated patients with anaplastic Wilms tumors registered in the UK SIOP‐WT‐2001 and IMPORT study cohorts (2002‐2020)
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DOI: 10.1002/cncr.34107
Abstract: Since the International Society of Paediatric Oncology Wilms' Tumour 2001 (SIOP‐WT‐2001) study, focal anaplastic Wilms tumors (FAWTs) have been treated as intermediate‐risk Wilms tumors (WTs), and diffuse anaplastic Wilms tumors (DAWTs) have been treated as… read more here.
Keywords: study; characteristics outcomes; siop 2001; outcomes preoperatively ... See more keywords
Extrarenal Anaplastic Wilms Tumor: A Case Report With Genomic Analysis and Tumor Models
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DOI: 10.1097/mph.0000000000002413
Abstract: Primary extrarenal Wilms tumors are rare neoplasms that are presumed to arise from metanephric or mesonephric remnants outside of the kidney. Their pathogenesis is debated but has not been studied, and there are no reports… read more here.
Keywords: primary extrarenal; wilms tumor; tumor models; extrarenal wilms ... See more keywords
Abstract 2689: Targeting the proteasome pathway in dactinomycin resistant Wilms tumors
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DOI: 10.1158/1538-7445.am2023-2689
Abstract: Nephroblastomas or Wilms tumors are the most common pediatric renal cancer. Across all cases, the 5-year overall survival is over 90%. This is largely in part due to brute-force, chemotherapy regimens such as dactinomycin (actD)… read more here.
Keywords: targeting proteasome; wilms; dactinomycin; tumor ... See more keywords
Rhabdomyosarcoma and Wilms tumors contain a subpopulation of noggin producing, myogenic cells immunoreactive for lens beaded filament proteins
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DOI: 10.1371/journal.pone.0214758
Abstract: Myo/Nog cells are identified by their expression of the skeletal muscle specific transcription factor MyoD and the bone morphogenetic protein inhibitor noggin, and binding of the G8 monoclonal antibody. Their release of noggin is critical… read more here.
Keywords: filament proteins; lens beaded; wilms tumors; myo nog ... See more keywords
Identification of hub genes and construction of prognostic nomogram for patients with Wilms tumors
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DOI: 10.3389/fonc.2022.982110
Abstract: Background In children, Wilms’ tumors are the most common urological cancer with unsatisfactory prognosis, but few molecular prognostic markers have been discovered for it. With the rapid development of high-throughput quantitative proteomic and transcriptomic approaches,… read more here.
Keywords: hub genes; prognostic nomogram; gene; patients wilms ... See more keywords
Somatic, Genetic and Epigenetic Changes in Nephrogenic Rests and Their Role in the Transformation to Wilms Tumors, a Systematic Review
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DOI: 10.3390/cancers15051363
Abstract: Simple Summary We reviewed all studies investigating molecular changes in nephrogenic rests (NR), the presumed precursor lesions of Wilms tumors (WT) being the most frequent malignant childhood renal tumors, between 1990 and 2022. Only 23… read more here.
Keywords: review; changes nephrogenic; somatic genetic; nephrogenic rests ... See more keywords
Characterization of Continuous Transcriptional Heterogeneity in High-Risk Blastemal-Type Wilms’ Tumors Using Unsupervised Machine Learning
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DOI: 10.3390/ijms24043532
Abstract: Wilms’ tumors are pediatric malignancies that are thought to arise from faulty kidney development. They contain a wide range of poorly differentiated cell states resembling various distorted developmental stages of the fetal kidney, and as… read more here.
Keywords: heterogeneity high; blastemal type; risk blastemal; high risk ... See more keywords