The Win Ratio Method in Heart Failure Trials: Lessons Learnt From Empulse.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of heart failure"
DOI: 10.1002/ejhf.2853
Abstract: AIMS The EMPULSE trial evaluated the clinical benefit of empagliflozin versus placebo using the stratified win ratio approach in 530 patients with acute heart failure (HF) after initial stabilization. We aim to elucidate how this… read more here.
Keywords: ratio; win ratio; heart failure;
Sample size formula for a win ratio endpoint
Sign Up to like & getrecommendations! Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9297
Abstract: The win ratio composite endpoint, which organizes the components of the composite hierarchically, is becoming popular in late‐stage clinical trials. The method involves comparing data in a pair‐wise manner starting with the endpoint highest in… read more here.
Keywords: sample size; endpoint; win ratio; size ... See more keywords
The stratified win ratio
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2017.1397007
Abstract: ABSTRACT The win ratio was first proposed in 2012 by Pocock and his colleagues to analyze a composite endpoint while considering the clinical importance order and the relative timing of its components. It has attracted… read more here.
Keywords: ratio; mantel haenszel; odds ratio; variance ... See more keywords
A win ratio approach for comparing crossing survival curves in clinical trials.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biopharmaceutical statistics"
DOI: 10.1080/10543406.2023.2170393
Abstract: Many clinical trials include time-to-event or survival data as an outcome. To compare two survival distributions, the log-rank test is often used to produce a P-value for a statistical test of the null hypothesis that… read more here.
Keywords: win ratio; test; cox model; treatment ... See more keywords
A class of proportional win-fractions regression models for composite outcomes.
Sign Up to like & getrecommendations! Published in 2020 at "Biometrics"
DOI: 10.1111/biom.13382
Abstract: The win ratio is gaining traction as a simple and intuitive approach to analysis of prioritized composite endpoints in clinical trials. To extend it from two-sample comparison to regression, we propose a novel class of… read more here.
Keywords: regression; class; two sample; win ratio ... See more keywords
On recurrent-event win ratio
Sign Up to like & getrecommendations! Published in 2022 at "Statistical Methods in Medical Research"
DOI: 10.1177/09622802221084134
Abstract: The win ratio approach proposed by Pocock et al. (2012) has become a popular tool for analyzing composite endpoints of death and non-fatal events like hospitalization. Its standard version, however, draws on the non-fatal event… read more here.
Keywords: win ratio; event; last event; event assisted ... See more keywords