Long lasting effects of chronic WIN55,212-2 treatment on mesostriatal dopaminergic and cannabinoid systems in the rat brain
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.11.005
Abstract: ABSTRACT Cannabinoid administration modulates dopamine transmission via an indirect, multisynaptic mechanism that includes the activation of cannabinoid type‐1 receptor (CB1R). The present study evaluated in rodents, the effects of acute and chronic (20 days) WIN55,212–2… read more here.
Keywords: administration; chronic win55; treatment; cannabinoid ... See more keywords
The effects of cannabinoid receptors activation and glucocorticoid receptors deactivation in the amygdala and hippocampus on the consolidation of a traumatic event
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2017.08.004
Abstract: Ample evidence demonstrates that fear learning contributes significantly to many anxiety pathologies including post-traumatic stress disorder (PTSD). The endocannabinoid (eCB) system may offer therapeutic benefits for PTSD and it is a modulator of the hypothalamic… read more here.
Keywords: consolidation; glucocorticoid receptors; traumatic event; win55 212 ... See more keywords
Cannabinoid WIN55,212-2 reprograms monocytes and macrophages to inhibit LPS-induced inflammation
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1147520
Abstract: Introduction Chronic or uncontrolled activation of myeloid cells including monocytes, macrophages and dendritic cells (DCs) is a hallmark of immune-mediated inflammatory disorders. There is an urgent need for the development of novel drugs with the… read more here.
Keywords: win55 212; capacity; monocytes macrophages; myeloid cells ... See more keywords
Cannabinoid Receptor Agonist WIN55, 212-2 Attenuates Injury in the Hippocampus of Rats after Deep Hypothermic Circulatory Arrest
Sign Up to like & getrecommendations! Published in 2023 at "Brain Sciences"
DOI: 10.3390/brainsci13030525
Abstract: Objectives: Postoperative neurological deficits remain a challenge in cardiac surgery employing deep hypothermic circulatory arrest (DHCA). This study aimed to investigate the effect of WIN55, 212-2, a cannabinoid agonist, on brain injury in a rat… read more here.
Keywords: circulatory arrest; win55 212; dhca; deep hypothermic ... See more keywords