The long and winding road of designing phosphodiesterase inhibitors for the treatment of heart failure.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.113123
Abstract: Cyclic nucleotide phosphodiesterases (PDEs) are a superfamily of enzymes known to play a critical role in the indirect regulation of several intracellular metabolism pathways through the selective hydrolysis of the phosphodiester bonds of specific second… read more here.
Keywords: road designing; winding road; long winding; heart failure ... See more keywords
Immunotherapy biomarkers: the long and winding road
Sign Up to like & getrecommendations! Published in 2021 at "Nature Reviews Clinical Oncology"
DOI: 10.1038/s41571-021-00498-w
Abstract: A recent meta-analysis examined and validated biomarkers of response to immune-checkpoint inhibitors (ICIs). Herein, we discuss the findings of this analysis, which are consistent with previously identified determinants of ICI efficacy and demonstrate that some… read more here.
Keywords: immunotherapy biomarkers; long winding; oncology; winding road ... See more keywords
Metropolisation: the winding road toward the citification of the region
Sign Up to like & getrecommendations! Published in 2020 at "Urban Geography"
DOI: 10.1080/02723638.2020.1828558
Abstract: ABSTRACT We aim to consolidate the concept of metropolisation as a lens to examine urban region integration in territories characterized by extensive urbanization. Metropolisation is defined as the process through which institutionally, functionally, and spatially… read more here.
Keywords: citification region; metropolisation; metropolisation winding; winding road ... See more keywords
On a Long and Winding Road: Alloantibodies in Organ Transplantation.
Sign Up to like & getrecommendations! Published in 2023 at "Transplantation"
DOI: 10.1097/tp.0000000000004550
Abstract: Today we know that both the humoral and the cellular arm of the immune system are engaged in severe immunological challenges. A close interaction between B and T cells can be observed in most "natural"… read more here.
Keywords: winding road; road alloantibodies; long winding; transplantation long ... See more keywords
Seizure forecasting: bifurcations in the long and winding road.
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia"
DOI: 10.1111/epi.17311
Abstract: To date the unpredictability of seizures remains a source of suffering for people with epilepsy, motivating decades of research into methods to forecast seizures. Originally, only few scientists and neurologists ventured into this niche endeavor,… read more here.
Keywords: seizure; winding road; long winding; forecasting bifurcations ... See more keywords
Authors reply: The long and winding road of COVID‐19 in survivors of hospitalization
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Internal Medicine"
DOI: 10.1111/joim.13603
Abstract: We thank Dr. Oscar Jolobe for his insightful report [1] in response to our article [2]. Nirmatrelvir has surged as an orally administered antiviral agent that reduces coronavirus replication by inhibiting the SARS-CoV-2 3-chymotrypsin–like cysteine… read more here.
Keywords: road covid; reply long; covid survivors; winding road ... See more keywords
Repairing the effects of childhood trauma: The long and winding road.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of psychiatric and mental health nursing"
DOI: 10.1111/jpm.12581
Abstract: What is known on this subject. Domestic and family violence contributes to mental distress and the development of mental illness and can reverberate throughout a person's life. What this paper adds to existing knowledge. Therapeutic… read more here.
Keywords: trauma long; childhood trauma; effects childhood; repairing effects ... See more keywords
The long and winding road of discontinuing long-term use of antidepressants: learning from my experience.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of psychiatric and mental health nursing"
DOI: 10.1111/jpm.12623
Abstract: What is known on the subject? More people experience withdrawal symptoms when weaning off antidepressants than previously thought; particularly after taking them for a long time. What this paper adds to existing knowledge. I explore… read more here.
Keywords: discontinuing long; long winding; road discontinuing; withdrawal symptoms ... See more keywords
Treatments in Neurology: The Winding Road from 1897 to 2022
Sign Up to like & getrecommendations! Published in 2022 at "European Neurology"
DOI: 10.1159/000525689
Abstract: Background: For many years, neurology was seen as a purely observational discipline, focused on pathology and with little interest in treatments. Summary: From the creation in 1897 of Monatsschrift für Psychiatrie und Neurologie, the forebear… read more here.
Keywords: neurology winding; neurology; winding road; treatments neurology ... See more keywords
Totally Rad? The Long and Winding Road to Understanding CaV1.2 Regulation.
Sign Up to like & getrecommendations! Published in 2021 at "Circulation Research"
DOI: 10.1161/circresaha.120.318493
Abstract: It has been clear for over 100 years that Ca 2+ and catecholamines perform central roles necessary for sustaining and modulating heart function. However, despite years of study, the cellular and molecular mechanisms underpinning adrenergic… read more here.
Keywords: rad long; ca2; winding road; long winding ... See more keywords
The Long and Winding Road of Atrial Septostomy
Sign Up to like & getrecommendations! Published in 2020 at "Diagnostics"
DOI: 10.3390/diagnostics10110971
Abstract: Almost forty years have elapsed since the first description of the use of atrial septostomy in the setting of pulmonary arterial hypertension (PAH) [...]. read more here.
Keywords: road atrial; septostomy; atrial septostomy; long winding ... See more keywords