WIP1 dephosphorylation of p27Kip1 Serine 140 destabilizes p27Kip1 and reverses anti-proliferative effects of ATM phosphorylation
Sign Up to like & getrecommendations! Published in 2020 at "Cell Cycle"
DOI: 10.1080/15384101.2020.1717025
Abstract: ABSTRACT The phosphoinositide-3-kinase like kinases (PIKK) such as ATM and ATR play a key role in initiating the cellular DNA damage response (DDR). One key ATM target is the cyclin-dependent kinase inhibitor p27Kip1 that promotes… read more here.
Keywords: p27kip1; p27kip1 serine; serine 140; wip1 ... See more keywords
MiR-145-5p Inhibits the Invasion of Prostate Cancer and Induces Apoptosis by Inhibiting WIP1
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DOI: 10.1155/2021/4412705
Abstract: Prostate cancer (PCa) is a common malignant tumor of the male genitourinary system that seriously affects the quality of life of patients. Studying the pathogenesis and therapeutic targets of PCa is important. In this study,… read more here.
Keywords: mir 145; wip1; pca; invasion ... See more keywords
A Study on the Role of Wip1 in Renal Fibrosis by Modulating Macrophage Phenotype.
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DOI: 10.21203/rs.3.rs-1222762/v1
Abstract: BACKGROUND Renal fibrosis is the result of chronic kidney diseases, the exploration of the pathogenesis of renal fibrosis and the development of effective treatment methods have become major challenges. AIMS To investigate the effect of… read more here.
Keywords: wip1; macrophage phenotype; role; renal fibrosis ... See more keywords
Tipping Growth Inhibition into Apoptosis by Combining Treatment with MDM2 and WIP1 Inhibitors in p53WT Uterine Leiomyosarcoma
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DOI: 10.3390/cancers14010014
Abstract: Simple Summary Uterine Leiomyosarcoma (uLMS) is a rare (0.8 per 100,000 women), aggressive cancer that predominantly affects post-menopausal women. Prognosis for these women is poor, with relapse following primary treatment occurring in up to 70%… read more here.
Keywords: apoptosis; inhibition; wip1; treatment ... See more keywords
Wild-type p53-induced Phosphatase 1 Deficiency Exacerbates Myocardial Infarction-induced Ischemic Injury
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DOI: 10.4103/0366-6999.206353
Abstract: Background: Myocardial infarction (MI) is a major disease burden. Wild-type p53-induced phosphatase 1 (Wip1) has been studied extensively in the context of cancer and the regulation of different types of stem cells, but the role… read more here.
Keywords: wip1; wild type; mice; cardiac function ... See more keywords