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Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.2139/ssrn.4200127
Abstract: Wiskostatin (1-(3,6-dibromo-9H-carbazol-9-yl)-3-(dimethylamino)propan-2-ol) (1) is a carbazole-based compound reported as a specific and relatively potent inhibitor of the N-WASP actin remodelling complex (S-isomer EC50 = 4.35 μM; R-isomer EC50 = 3.44 μM). An NMR solution structure showed that wiskostatin interacts with a…
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Keywords:
carbazol;
wiskostatin;
gtpase activity;
dynamin gtpase ... See more keywords