Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors.
Sign Up to like & getrecommendations! Published in 2019 at "Cell stem cell"
DOI: 10.1016/j.stem.2018.12.014
Abstract: Research on age-related regenerative failure of skeletal muscle has extensively focused on the phenotypes of muscle stem cells (MuSCs). In contrast, the impact of aging on regulatory cells in the MuSC niche remains largely unexplored.… read more here.
Keywords: muscle; fibro adipogenic; muscle stem; cell ... See more keywords
EPCO-11. IN VIVO FUNCTIONAL GENOMIC SCREEN IDENTIFIES WISP1 AS AN OVEREXPRESSED DRIVER OF GLIOBLASTOMA
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.290
Abstract: There is a tremendous need to identify new genetic drivers of glioblastoma which can serve as potential therapeutic targets. In order to find new drivers, we leveraged genomic datasets to conduct a context specific in… read more here.
Keywords: driver; functional genomic; vivo functional; overexpressed driver ... See more keywords