Preparation and characterization of anticancer niosomal withaferin–A formulation for improved delivery to cancer cells: In vitro, in vivo, and in silico evaluation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2020.101863
Abstract: Abstract Novel synthetic variants of niosomes and their use as a carrier of anticancer drugs are promising in the field of oncology. In the present study, a non–ionic surfactant and cholesterol-based system were used in… read more here.
Keywords: withaferin; delivery; formulation; preparation characterization ... See more keywords
Semi-synthesis of a novel hybrid isoxazolidino withaferin via chemoselective and diastereoselective 1,3-dipolar nitrone cycloaddition reaction
Sign Up to like & getrecommendations! Published in 2019 at "Natural Product Research"
DOI: 10.1080/14786419.2019.1582045
Abstract: Abstract A facile, atom-economic synthesis of isoxazilidino withaferin, a novel hybrid of withaferin A, has been accomplished via two-step reaction of nitrone synthesis followed by nitrone 1,3-dipolar cycloaddition. The reaction is highly chemoselective (preferential reaction… read more here.
Keywords: withaferin; nitrone; reaction; cycloaddition reaction ... See more keywords