Biotin Mitigates Alcohol Withdrawal‐Induced Anxiety and Depression by Regulating Serotonin Metabolism, BDNF, Inflammation, and Oxidative Stress in Rats
Sign Up to like & getrecommendations! Published in 2025 at "Neuropsychopharmacology Reports"
DOI: 10.1002/npr2.12523
Abstract: Substance use disorders, particularly alcohol use disorders, represent a significant public health problem, with adolescents particularly vulnerable to their adverse effects. This study examined the possible anxiolytic and antidepressant effects of biotin, a crucial vitamin… read more here.
Keywords: withdrawal induced; withdrawal; alcohol withdrawal; biotin mitigates ... See more keywords
Effects of CB1 receptor negative allosteric modulator Org27569 on oxycodone withdrawal symptoms in mice
Sign Up to like & getrecommendations! Published in 2024 at "Psychopharmacology"
DOI: 10.1007/s00213-024-06591-z
Abstract: Rationale/Objectives Targeting cannabinoid receptor type 1 (CB1R) has shown promise for treating opioid withdrawal symptoms. This study aimed to investigate the efficacy of a specific CB1R negative allosteric modulator (NAM), Org27569, in reducing both naloxone-precipitated… read more here.
Keywords: oxycodone; withdrawal induced; naloxone precipitated; withdrawal ... See more keywords
Inhibitory Influence of Agmatine in Ethanol Withdrawal-Induced Depression in Rats: Behavioral and Neurochemical Evidences.
Sign Up to like & getrecommendations! Published in 2019 at "Alcohol"
DOI: 10.1016/j.alcohol.2019.09.002
Abstract: Although ethanol withdrawal depression is one of the prominent reasons for its reinstatement and dependence, its neurochemical basis is not clearly understood. Present study investigated the role of agmatinergic system in ethanol withdrawal-induced depression using… read more here.
Keywords: ethanol withdrawal; withdrawal induced; withdrawal; rat ... See more keywords
Stimulation of dorsal hippocampal histaminergic transmission mitigates the expression of ethanol withdrawal-induced despair in mice.
Sign Up to like & getrecommendations! Published in 2021 at "Alcohol"
DOI: 10.1016/j.alcohol.2021.06.002
Abstract: Garnered literature points towards the role of the dorsal hippocampus (CA1) in ethanol withdrawal-induced responses, wherein a strong presence of the histaminergic system is also reported. Therefore, the present study investigated the effect of an… read more here.
Keywords: withdrawal; induced despair; withdrawal induced; ethanol withdrawal ... See more keywords
Precipitated Withdrawal Induced by Prehospital Naloxone Administration
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DOI: 10.1080/10903127.2024.2449505
Abstract: Abstract Objectives Buprenorphine is becoming a key component of prehospital management of opioid use disorder. It is unclear how many prehospital patients might be eligible for buprenorphine induction, as traditional induction requires that patients first… read more here.
Keywords: precipitated withdrawal; withdrawal induced; withdrawal; administration ... See more keywords
Neuronal nicotinic acetylcholine receptor of the central amygdala modulates the ethanol-induced tolerance to anxiolysis and withdrawal-induced anxiety in male rats
Sign Up to like & getrecommendations! Published in 2024 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000770
Abstract: The nicotine acetylcholinergic receptor (nAchR) in the central nucleus of the amygdala (CeA) is known to modulate anxiety traits as well as ethanol-induced behavioral effects. Therefore, the present study investigated the role of CeA nAChR… read more here.
Keywords: anxiety; ethanol induced; withdrawal induced; tolerance ... See more keywords
The Mammalian Circadian Clock Exhibits Chronic Ethanol Tolerance and Withdrawal‐Induced Glutamate Hypersensitivity, Accompanied by Changes in Glutamate and TrkB Receptor Proteins
Sign Up to like & getrecommendations! Published in 2018 at "Alcoholism: Clinical and Experimental Research"
DOI: 10.1111/acer.13554
Abstract: BACKGROUND Alcohol tolerance and withdrawal-induced effects are criteria for alcohol use disorders listed by the DSM-V. Although tolerance and withdrawal have been studied over many decades, there is still uncertainty regarding mechanistic distinctions that characterize… read more here.
Keywords: tolerance; withdrawal induced; glutamate hypersensitivity; withdrawal ... See more keywords
Inhibition of the Sodium Calcium Exchanger Suppresses Alcohol Withdrawal-Induced Seizure Susceptibility
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DOI: 10.3390/brainsci11020279
Abstract: Calcium influx plays important roles in the pathophysiology of seizures, including acoustically evoked alcohol withdrawal-induced seizures (AWSs). One Ca2+ influx route of interest is the Na+/Ca2+ exchanger (NCX) that, when operating in its reverse mode… read more here.
Keywords: seizure; alcohol withdrawal; susceptibility; withdrawal induced ... See more keywords