Promiscuous attraction of ligands within the ATP binding site of RyR2 promotes diverse gating behaviour
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DOI: 10.1038/s41598-018-33328-8
Abstract: ATP is an essential constitutive regulator of cardiac ryanodine receptors (RyR2), enabling small changes in cytosolic Ca2+ to trigger large changes in channel activity. With recent landmark determinations of the full structures of RyR1 (skeletal… read more here.
Keywords: binding site; ryr2; atp binding; promiscuous attraction ... See more keywords