Encapsulation of Mitoxantrone within Cucurbit[8]uril Decreases Toxicity and Enhances Survival in a Mouse Model of Cancer.
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DOI: 10.1021/acsmedchemlett.7b00090
Abstract: Mitoxantrone was efficiently encapsulated within cucurbit[8]uril in a 2:1 complex where the two mitoxantrone molecules were symmetrically located through both portals of a cucurbit[8]uril cage. The novel complex facilitates increased mitoxantrone uptake in mouse breast… read more here.
Keywords: decreases toxicity; cucurbit uril; within cucurbit; cancer ... See more keywords