Variant-specific SARS-CoV-2 within-host kinetics.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medical virology"
DOI: 10.1002/jmv.27757
Abstract: Since early 2021, SARS-CoV-2 variants of concern (VOCs) have been causing epidemic rebounds in many countries. Their properties are well characterised at the epidemiological level but the potential underlying within-host determinants remain poorly understood. We… read more here.
Keywords: specific sars; within host; cov within; variant specific ... See more keywords
How does within‐host dynamics affect population‐level dynamics? Insights from an immuno‐epidemiological model of malaria
Sign Up to like & getrecommendations! Published in 2017 at "Mathematical Methods in The Applied Sciences"
DOI: 10.1002/mma.4466
Abstract: Malaria is one of the most common mosquito-borne diseases widespread in the tropical and subtropical regions. Few models coupling the within-host malaria dynamics with the between-host mosquito-human dynamics have been developed. In this paper, by… read more here.
Keywords: population level; reproduction; within host; model ... See more keywords
Modelling coupled within host and population dynamics of $$R_5$$R5 and $$X_4$$X4 HIV infection
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Mathematical Biology"
DOI: 10.1007/s00285-017-1170-1
Abstract: Most existing models have considered the immunological processes occurring within the host and the epidemiological processes occurring at population level as decoupled systems. We present a new model using continuous systems of non linear ordinary… read more here.
Keywords: host population; host dynamics; within host; population dynamics ... See more keywords
Within-Host Viral Dynamics in a Multi-compartmental Environment
Sign Up to like & getrecommendations! Published in 2019 at "Bulletin of Mathematical Biology"
DOI: 10.1007/s11538-019-00658-1
Abstract: The discrepancy in the turnover of cells and virus in different organs or viral reservoirs necessitates the investigation of multiple compartments within a host. Establishing a multi-compartmental structure that describes the complexity of various organs,… read more here.
Keywords: host viral; viral dynamics; multi compartmental; within host ... See more keywords
Sensitivity Analysis in an Immuno-Epidemiological Vector-Host Model
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DOI: 10.1007/s11538-021-00979-0
Abstract: Sensitivity Analysis (SA) is a useful tool to measure the impact of changes in model parameters on the infection dynamics, particularly to quantify the expected efficacy of disease control strategies. SA has only been applied… read more here.
Keywords: vector host; sensitivity analysis; host; disease ... See more keywords
Direct transmission of within-host Mycobacterium tuberculosis diversity to secondary cases can lead to variable between-host heterogeneity without de novo mutation: A genomic investigation
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.08.010
Abstract: Background Whole genome sequencing (WGS) has enabled the development of new approaches to track Mycobacterium tuberculosis (Mtb) transmission between tuberculosis (TB) cases but its utility may be challenged by the discovery that Mtb diversifies within… read more here.
Keywords: transmission; within host; case; host ... See more keywords
Detecting within-host interactions from genotype combination prevalence data
Sign Up to like & getrecommendations! Published in 2019 at "Epidemics"
DOI: 10.1016/j.epidem.2019.100349
Abstract: Parasite genetic diversity can provide information on disease transmission dynamics but most mathematical and statistical frameworks ignore the exact combinations of genotypes in infections. We introduce and validate a new method that combines explicit epidemiological… read more here.
Keywords: within host; prevalence data; detecting within; host ... See more keywords
Exposing the diversity of multiple infection patterns.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2017.02.011
Abstract: Natural populations often have to cope with genetically distinct parasites that can coexist, or not, within the same hosts. Theoretical models addressing the evolution of virulence have considered two within host infection outcomes, namely superinfection… read more here.
Keywords: infection; diversity multiple; within host; infection patterns ... See more keywords
Inferring within-host bottleneck size: A Bayesian approach.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2017.09.011
Abstract: Recent technical developments in microbiology have led to new discoveries on the within-host dynamics of bacterial infections in laboratory animals. In particular, they have highlighted the importance of stochastic bottlenecks at the onset of invasive… read more here.
Keywords: microbiology; bottleneck size; within host; bottleneck ... See more keywords
Unraveling within-host signatures of dengue infection at the population level.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2018.03.004
Abstract: Dengue virus causes worldwide concern with nearly 100 million infected cases reported annually. The within-host dynamics differ between primary and secondary infections, where secondary infections with a different virus serotype typically last longer, produce higher… read more here.
Keywords: population level; within host; model; host ... See more keywords
Immune response and within-host viral evolution: Immune response can accelerate evolution.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2018.08.003
Abstract: The objectives of this paper are to explore the impact of immune response on within-host viral evolution towards higher Darwinian fitness and, in particular, to verify a hypothesis that immune response, which is insufficient to… read more here.
Keywords: viral evolution; response; within host; model ... See more keywords