Histoplasma capsulatum Relies on Tryptophan Biosynthesis To Proliferate within the Macrophage Phagosome
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DOI: 10.1128/iai.00059-23
Abstract: Histoplasma capsulatum yeasts reside and proliferate within the macrophage phagosome during infection. This nutrient-depleted phagosomal environment imposes challenges to Histoplasma yeasts for nutrition acquisition. Histoplasma yeasts require all 20 amino acids, which can be formed… read more here.
Keywords: within macrophage; histoplasma; biosynthesis; macrophage phagosome ... See more keywords
Living Within the Macrophage: Dimorphic Fungal Pathogen Intracellular Metabolism
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DOI: 10.3389/fcimb.2020.592259
Abstract: Histoplasma and Paracoccidioides are related thermally dimorphic fungal pathogens that cause deadly mycoses (i.e., histoplasmosis and paracoccidioidomycosis, respectively) primarily in North, Central, and South America. Mammalian infection results from inhalation of conidia and their subsequent… read more here.
Keywords: metabolism; macrophage dimorphic; within macrophage; dimorphic fungal ... See more keywords