RNF4 and USP7 coordinate spatial regulation of SLX4 stability within the PML nuclear bodies
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DOI: 10.1093/nar/gkaf941
Abstract: Abstract To protect the genome from the formation of DNA breaks by nucleases involved in DNA repair, cells have evolved multiple levels of regulatory strategies. One key regulator of nuclease activity is the scaffold protein… read more here.
Keywords: slx4 stability; within pml; nuclear bodies; slx4 ... See more keywords
An Atypical PML-RARA Rearrangement Resulting from Submicroscopic Insertion of the RARA Gene at the PML Locus with Novel Breakpoints within PML Exon 7b and RARA Exon 3
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DOI: 10.1159/000498842
Abstract: The diagnostic hallmark of acute promyelocytic leukemia (APL) is the reciprocal translocation t(15;17), resulting in the characteristic PML-RARA fusion; however, patients occasionally have masked PML-RARArearrangements. We report an APL case with no evidence of t(15;17)… read more here.
Keywords: rara; novel breakpoints; within pml; pml rara ... See more keywords