Fingolimod interrupts the cross talk between estrogen metabolism and sphingolipid metabolism within prostate cancer cells.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2018.04.008
Abstract: Sphingolipids are critical regulators of tumor microenvironments and play an important role in estrogen-dependent cancers. Estrogen and estrogen metabolites were found to be involved in prostate cancer. Fingolimod (FTY720) is a sphingokinase-1 (SphK1) inhibitor with… read more here.
Keywords: metabolism; estrogen; prostate cancer; within prostate ... See more keywords
Structural Variations of the Prostatic Urethra Within the Prostate Predict the Severities of Obstructive Symptoms: A Prospective Multicenter Observational Study.
Sign Up to like & getrecommendations! Published in 2017 at "Urology"
DOI: 10.1016/j.urology.2017.03.014
Abstract: OBJECTIVE To describe distinctive morphologic variations of the prostate associated with the prostatic urethra, and to determine whether structural changes of the urethra within the prostate resulting from gland enlargement, rather than prostrate volume itself,… read more here.
Keywords: volume; rpul; within prostate; prostatic urethra ... See more keywords