Privileged Structures and Polypharmacology within and between Protein Families
Sign Up to like & getrecommendations! Published in 2018 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.8b00364
Abstract: Polypharmacology is often a key contributor to the efficacy of a drug, but is also a potential risk. We investigated two hits discovered via a cell-based phenotypic screen, the CDK9 inhibitor CCT250006 (1) and the… read more here.
Keywords: protein families; privileged structures; polypharmacology; polypharmacology within ... See more keywords
An association test of the spatial distribution of rare missense variants within protein structures identifies Alzheimer's disease–related patterns
Sign Up to like & getrecommendations! Published in 2022 at "Genome Research"
DOI: 10.1101/gr.276069.121
Abstract: More than 90% of genetic variants are rare in most modern sequencing studies, such as the Alzheimer's Disease Sequencing Project (ADSP) whole-exome sequencing (WES) data. Furthermore, 54% of the rare variants in ADSP WES are… read more here.
Keywords: variants within; within protein; missense; spatial distribution ... See more keywords
Bacterial Noncoding RNAs Excised from within Protein-Coding Transcripts
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DOI: 10.1128/mbio.01730-18
Abstract: Bacteria and archaea utilize regulatory small noncoding RNAs (ncRNAs) to control the expression of specific genetic programs. These ncRNAs are almost exclusively encoded within intergenic regions and are independently transcribed. Here, we report on a… read more here.
Keywords: protein; within protein; expression; large set ... See more keywords