Sign epistasis caused by hierarchy within signalling cascades
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03644-8
Abstract: Sign epistasis is a central evolutionary constraint, but its causal factors remain difficult to predict. Here we use the notion of parameterised optima to explain epistasis within a signalling cascade, and test these predictions in… read more here.
Keywords: sign epistasis; within signalling; hierarchy; epistasis ... See more keywords