WNK4 kinase: role of chloride sensing in the distal convoluted tubule
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Nephrology and Hypertension"
DOI: 10.1097/mnh.0000000000000683
Abstract: Purpose of review This review focuses on recent efforts in identifying with-no-lysine kinase 4 (WNK4) as a physiological intracellular chloride sensor and exploring regulators of intracellular chloride concentration ([Cl-]i) in the distal convoluted tubule (DCT).… read more here.
Keywords: convoluted tubule; wnk4; distal convoluted; chloride ... See more keywords
WNK4 limits distal calcium losses following acute furosemide treatment
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DOI: 10.14814/phy2.14195
Abstract: The distal nephron is essential for calcium homeostasis. This is evidenced by disordered calcium transport following disrupted distal nephron function occurring in saltâwasting tubulopathies or with diuretic use. A plethora of studies support a role… read more here.
Keywords: distal nephron; wnk4; treatment; following acute ... See more keywords
MST3 Involvement in Na+ and K+ Homeostasis with Increasing Dietary Potassium Intake.
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DOI: 10.3390/ijms22030999
Abstract: K+ loading inhibits NKCC2 (Na-K-Cl cotransporter) and NCC (Na-Cl cotransporter) in the early distal tubules, resulting in Na+ delivery to the late distal convoluted tubules (DCTs). In the DCTs, Na+ entry through ENaC (epithelial Na… read more here.
Keywords: homeostasis; potassium; mst3; wnk4 ... See more keywords