Magnetic Mechanoactivation of Wnt Signaling Augments Dopaminergic Differentiation of Neuronal Cells
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Biosystems"
DOI: 10.1002/adbi.201900091
Abstract: Wnt signaling is a key developmental pathway that regulates dopaminergic progenitor cell proliferation and differentiation during neuronal development. This makes Wnt signaling an important therapeutic target for neurodegenerative conditions such as Parkinson's disease. Wnt signaling… read more here.
Keywords: wnt signaling; wnt; magnetic mechanoactivation; differentiation neuronal ... See more keywords
Bu‐Shen‐Huo‐Xue‐Fang modulates nucleus pulposus cell proliferation and extracellular matrix remodeling in intervertebral disk degeneration through miR‐483 regulation of Wnt pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26760
Abstract: Intervertebral disk degeneration (IDD) has been widely considered as one of the main causes for low back pain, which can cause a severe impact to human health and huge economic burden to worldwide society. IDD… read more here.
Keywords: disk degeneration; cell proliferation; intervertebral disk; wnt ... See more keywords
Battle in stem cell niches: Canonical versus noncanonical Wnt signaling
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.2ce1117-453rr
Abstract: Stem cell niches are specialized microenvironments that regulate stem cell-specific properties, including multipotentiality, self-renewal, and quiescence. Wnt signaling in stem cell niches plays a critical role in regulating stem cells from multiple tissues, including embryonic,… read more here.
Keywords: noncanonical wnt; wnt signaling; wnt; stem cell ... See more keywords
ARHGEF40 promotes non‐small cell lung cancer proliferation and invasion via the AKT‐Wnt axis by binding to RhoA
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23457
Abstract: Rho guanine nucleotide exchange factor 40 (ARHGEF40) is a member of the Dbl‐family of guanine nucleotide factor proteins. However, its expression pattern and biological function in malignant tumors, notably in nonsmall cell lung cancer (NSCLC)… read more here.
Keywords: lung cancer; cell; lung; arhgef40 ... See more keywords
Modulating the wnt signaling pathway with small molecules
Sign Up to like & getrecommendations! Published in 2017 at "Protein Science"
DOI: 10.1002/pro.3122
Abstract: Wnt signaling is a critical component during embryonic development and also plays an important role in regulating adult tissue homeostasis. Abnormal activation of Wnt signaling has been implicated in many cancers, while reduced activity of… read more here.
Keywords: pathway small; wnt signaling; wnt; modulating wnt ... See more keywords
Myometrial Cells Stimulate Self‐Renewal of Endometrial Mesenchymal Stem‐Like Cells Through WNT5A/β‐Catenin Signaling
Sign Up to like & getrecommendations! Published in 2019 at "STEM CELLS"
DOI: 10.1002/stem.3070
Abstract: Human endometrium undergoes cycles of proliferation and differentiation throughout the reproductive years of women. The endometrial stem/progenitor cells contribute to this regenerative process. They lie in the basalis layer of the endometrium next to the… read more here.
Keywords: wnt; catenin signaling; myometrial cells; self renewal ... See more keywords
Controlling Wnt Signaling Specificity and Implications for Targeting WNTs Pharmacologically.
Sign Up to like & getrecommendations! Published in 2021 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2021_529
Abstract: Wnt signaling is critical for proper development of the embryo and for tissue homeostasis in the adult. Activation of this signaling cascade is initiated by binding of the secreted Wnts to their receptors. With the… read more here.
Keywords: specificity implications; wnt signaling; wnt; implications targeting ... See more keywords
Wnt Signalling-Targeted Therapy in the CMS2 Tumour Subtype: A New Paradigm in CRC Treatment?
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-02771-1_6
Abstract: Colorectal cancers (CRC) belonging to the consensus molecular subtype 2 (CMS2) have the highest incidence rate, affect mainly the distal colon and rectum, and are characterized by marked Wnt/β-catenin/Transcription Factor 7-Like 2 (TCF7L2) pathway activation… read more here.
Keywords: cms2; wnt; treatment; wnt signalling ... See more keywords
Wnt Signaling in Osteosarcoma.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-43085-6_8
Abstract: Wnt molecules are a class of cysteine-rich secreted glycoproteins that participate in various developmental events during embryogenesis and adult tissue homeostasis. Since its discovery in 1982, the roles of Wnt signaling have been established in… read more here.
Keywords: wnt signaling; wnt; signaling pathway; biology ... See more keywords
Differential Regulation of Wnt Signaling Components During Hippocampal Reorganization After Entorhinal Cortex Lesion
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-020-00870-x
Abstract: Entorhinal cortex lesions have been established as a model for hippocampal deafferentation and have provided valuable information about the mechanisms of synapse reorganization and plasticity. Although several molecules have been proposed to contribute to these… read more here.
Keywords: entorhinal cortex; wnt signaling; wnt; signaling components ... See more keywords
Investigation of Atrial Natriuretic Peptide as A Competitive Inhibitory Candidate Against Wnt/β-Catenin Signalling: A Molecular Dynamics Approach
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-020-10085-9
Abstract: Wnt/β-catenin signaling, a highly evolutionary conserved pathway, is abnormally regulated in many human cancers. This pathway is one of the proposed mechanisms of atrial natriuretic peptide (ANP) anti-cancer effect. ANP which at first reported as… read more here.
Keywords: atrial natriuretic; wnt; molecular dynamics; dynamics approach ... See more keywords