WNT-activated embryonal tumors of the pineal region: ectopic medulloblastomas or a novel pineoblastoma subgroup?
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica"
DOI: 10.1007/s00401-020-02208-9
Abstract: Pineoblastoma (PB) is a CNS embryonal tumor of childhood with propensity to metastasize and a 5-year overall survival of 61% [5]. Originating from the pineal gland, PBs carry molecular profiles distinct from medulloblastomas (MBs), the… read more here.
Keywords: wnt activated; pineal region; embryonal tumors; pineoblastoma ... See more keywords
Wnt-activated olfactory ensheathing cells stimulate neural stem cell proliferation and neuronal differentiation
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research"
DOI: 10.1016/j.brainres.2020.146726
Abstract: Olfactory ensheathing cells (OECs) are special glial cells localized in olfactory system which secrete large number of neurotrophic factors and promote the migration and survival of neurons. Canonical Wnt/β-catenin signaling is activated in OECs during… read more here.
Keywords: wnt; olfactory ensheathing; proliferation; wnt activated ... See more keywords
A CTNNB1‐altered medulloblastoma shows the immunophenotypic, DNA methylation and transcriptomic profiles of SHH‐activated, and not WNT‐activated, medulloblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12815
Abstract: Recent advancements in molecular characterisation have identified four principal molecular groups of medulloblastoma: WNT, SHH, group 3 and group 4. Each has its characteristic clinical features, signature genetic alterations and distinct DNA methylome profiles. Thus… read more here.
Keywords: wnt activated; activated medulloblastoma; dna methylation; medulloblastoma ... See more keywords