Increased expression of the thyroid hormone nuclear receptor TRα1 characterizes intestinal tumors with high Wnt activity
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DOI: 10.18632/oncotarget.25741
Abstract: Our previous work demonstrated a key function of the thyroid hormone nuclear receptor TRα1, a T3-modulated transcription factor, in controlling intestinal development and homeostasis via the Wnt and Notch pathways. Importantly, increased expression of TRα1… read more here.
Keywords: wnt activity; expression; nuclear receptor; hormone nuclear ... See more keywords
P-cadherin mutations are associated with high basal Wnt activity and stemness in canine mammary tumor cell lines
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DOI: 10.18632/oncotarget.26873
Abstract: ABSTRACT Purpose: To find underlying mutations causing highly-activated Wnt activity in mammary tumor cell lines associated with rounded morphology indicative of stemness/EMT. Methods: Stemness of high Wnt cell lines was confirmed using qPCR on selected… read more here.
Keywords: wnt; cell lines; wnt activity; mammary tumor ... See more keywords
Replication Study: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
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DOI: 10.7554/elife.45426
Abstract: As part of the Reproducibility Project: Cancer Biology we published a Registered Report (Evans et al., 2015), that described how we intended to replicate selected experiments from the paper ‘Wnt activity defines colon cancer stem… read more here.
Keywords: colon cancer; activity; wnt activity; study ... See more keywords