Wnt/BMP mediated metabolic reprogramming preserves multipotency of neural crest like stem cells.
Sign Up to like & getrecommendations! Published in 2023 at "Stem cells"
DOI: 10.1093/stmcls/sxad001
Abstract: Neural Crest-like Stem cells resembling embryonic neural crest cells (NCs) can be derived from adult human tissues such as the epidermis. However, these cells lose their multipotency rapidly in culture limiting their expansion for clinical… read more here.
Keywords: like stem; neural crest; crest like; stem cells ... See more keywords
EED-mediated histone methylation is critical for CNS myelination and remyelination by inhibiting WNT, BMP, and senescence pathways
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aaz6477
Abstract: Polycomb repressive EED protein orchestrates WNT, BMP, and senescence pathways to ensure proper CNS myelination and repair. Mutations in the polycomb repressive complex 2 (PRC2) can cause Weaver-like syndrome, wherein a patient cohort exhibits abnormal… read more here.
Keywords: wnt bmp; cns myelination; bmp; bmp senescence ... See more keywords
New roles for Wnt and BMP signaling in neural anteroposterior patterning
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DOI: 10.15252/embr.201845842
Abstract: During amphibian development, neural patterning occurs via a two‐step process. Spemann's organizer secretes BMP antagonists that induce anterior neural tissue. A subsequent caudalizing step re‐specifies anterior fated cells to posterior fates such as hindbrain and… read more here.
Keywords: neural anteroposterior; roles wnt; wnt bmp; new roles ... See more keywords