DCZ0415, a small‐molecule inhibitor targeting TRIP13, inhibits EMT and metastasis via inactivation of the FGFR4/STAT3 axis and the Wnt/β‐catenin pathway in colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13201
Abstract: Thyroid receptor‐interacting protein 13 (TRIP13), a protein of the AAA‐ATPase family, is upregulated in various human cancers, including colorectal cancer (CRC). This study focused on the inhibition of TRIP13‐induced CRC progression and signalling by DCZ0415,… read more here.
Keywords: wnt catenin; trip13; dcz0415; crc ... See more keywords
GSTZ1‐1 downregulates Wnt/β‐catenin signalling in hepatocellular carcinoma cells
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12769
Abstract: Glutathione S‐transferase Zeta 1‐1 (GSTZ1‐1), an enzyme involved in the catabolism of phenylalanine and the detoxification of xenobiotics, plays a tumour suppressor role in hepatocellular carcinoma (HCC), but the underlying mechanism remains largely unknown. Here,… read more here.
Keywords: hepatocellular carcinoma; gstz1; analysis; catenin ... See more keywords
Reduced MAGI3 level by HPV18E6 contributes to Wnt/β-catenin signaling activation and cervical cancer progression.
Sign Up to like & getrecommendations! Published in 2021 at "FEBS open bio"
DOI: 10.1002/2211-5463.13298
Abstract: Human papillomavirus type 18 (HPV18) has high carcinogenic power in invasive cervical cancer (ICC) development. However, the underlying mechanism remains elusive. The carcinogenic properties of HPV18 require the PDZ-binding motif of its E6 oncoprotein (HPV18… read more here.
Keywords: catenin signaling; cervical cancer; activation; cancer ... See more keywords
Drug Self-Delivery Nanocubes Enhance O2 -Economized Photodynamic-Immunotherapy of Triple-Negative Breast Cancer by Downregulating Wnt/β-catenin Signaling.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202203019
Abstract: Although the combination of chemotherapy and immune checkpoint inhibitors (ICIs) can treat triple-negative breast cancer (TNBC), the severe effects of chemotherapy on immune cells significantly reduce the efficacy of the ICIs. Photodynamic therapy (PDT) with… read more here.
Keywords: wnt catenin; triple negative; breast cancer; catenin signaling ... See more keywords
Reversing MET‐Mediated Resistance in Oncogene‐Driven NSCLC by MET‐Activated Wnt Condensative Prodrug
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202400603
Abstract: The amplification of MET is a major cause of acquired resistance to targeted therapy in EGFR‐mutant non‐small‐cell lung cancer (NSCLC), only to be temporarily restrained by the partial efficacy of MET inhibitors. This study reveals… read more here.
Keywords: wnt catenin; resistance; wnt condensative; reversing met ... See more keywords
KLF1 Promotes Cardiomyocyte Proliferation and Heart Regeneration Through Regulation of Wnt/β‐Catenin Signaling Pathway
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202413964
Abstract: Innovative therapeutic approaches for heart failure, a leading cause of mortality worldwide, are urgently needed. In this study, the important role of Krüppel‐like factor 1 (KLF1) in cardiomyocyte proliferation and heart regeneration is explored, and… read more here.
Keywords: heart; proliferation heart; heart regeneration; wnt catenin ... See more keywords
SOX11 regulates apoptosis and cell cycle in hepatocellular carcinoma via Wnt/β‐catenin signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1718
Abstract: Hepatocellular carcinoma (HCC) is the most common type of liver cancer with high mortality. Identifying key molecules involved in the regulation of HCC development is of great clinical significance. SOX11 is a transcription factor belonging… read more here.
Keywords: hepatocellular carcinoma; hcc; catenin signaling; signaling pathway ... See more keywords
Mechano‐regulation of Wnt/β‐Catenin signaling to control paraxial versus lateral mesoderm lineage bifurcation
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Progress"
DOI: 10.1002/btpr.3312
Abstract: Mechanical cues are involved in many biological processes, including embryonic development and patterning. For example, external mechanical forces (shear stress), lateral cell–cell interactions, and mechanical properties (stiffness and composition) of the extracellular matrix are thought… read more here.
Keywords: stress; wnt catenin; catenin signaling; differentiation ... See more keywords
LINC00669 promotes lung adenocarcinoma growth by stimulating the Wnt/β‐catenin signaling pathway
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5604
Abstract: Lung cancer poses severe threats to human health. It is indispensable to discover more druggable molecular targets. We identified a novel dysregulated long non‐coding RNA (lncRNA), LINC00669, in lung adenocarcinoma (LUAD) by analyzing the TCGA… read more here.
Keywords: cell; lung adenocarcinoma; wnt catenin; risk ... See more keywords
Inhibition of MDFI attenuates proliferation and glycolysis of Helicobacter pylori‐infected gastric cancer cells by inhibiting Wnt/β‐catenin pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11907
Abstract: MyoD family inhibitor (MDFI) is a myogenic transcription factor regulatory protein. MDFI has been proven to be upregulated and to promote cell proliferation in colorectal cancer. However, the role of MDFI in gastric cancer (GC)… read more here.
Keywords: cell; proliferation glycolysis; wnt catenin; mdfi ... See more keywords
Wnt/β‐catenin pathway as a link between therapy resistance‐driven epithelial‐mesenchymal transition and stemness in colorectal cancer
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DOI: 10.1002/cbin.12270
Abstract: The high plasticity of cells undergoing epithelial‐mesenchymal transition (EMT) promotes increased tumor heterogeneity, and its interaction with tumor‐associated stromal cells appears to contribute to developing a stemness phenotype. Cells with these characteristics exhibit increased resistance… read more here.
Keywords: mesenchymal transition; cancer; resistance; catenin pathway ... See more keywords