DCZ0415, a small‐molecule inhibitor targeting TRIP13, inhibits EMT and metastasis via inactivation of the FGFR4/STAT3 axis and the Wnt/β‐catenin pathway in colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13201
Abstract: Thyroid receptor‐interacting protein 13 (TRIP13), a protein of the AAA‐ATPase family, is upregulated in various human cancers, including colorectal cancer (CRC). This study focused on the inhibition of TRIP13‐induced CRC progression and signalling by DCZ0415,… read more here.
Keywords: wnt catenin; trip13; dcz0415; crc ... See more keywords
GSTZ1‐1 downregulates Wnt/β‐catenin signalling in hepatocellular carcinoma cells
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12769
Abstract: Glutathione S‐transferase Zeta 1‐1 (GSTZ1‐1), an enzyme involved in the catabolism of phenylalanine and the detoxification of xenobiotics, plays a tumour suppressor role in hepatocellular carcinoma (HCC), but the underlying mechanism remains largely unknown. Here,… read more here.
Keywords: hepatocellular carcinoma; gstz1; analysis; catenin ... See more keywords
Reduced MAGI3 level by HPV18E6 contributes to Wnt/β-catenin signaling activation and cervical cancer progression.
Sign Up to like & getrecommendations! Published in 2021 at "FEBS open bio"
DOI: 10.1002/2211-5463.13298
Abstract: Human papillomavirus type 18 (HPV18) has high carcinogenic power in invasive cervical cancer (ICC) development. However, the underlying mechanism remains elusive. The carcinogenic properties of HPV18 require the PDZ-binding motif of its E6 oncoprotein (HPV18… read more here.
Keywords: catenin signaling; cervical cancer; activation; cancer ... See more keywords
Drug Self-Delivery Nanocubes Enhance O2 -Economized Photodynamic-Immunotherapy of Triple-Negative Breast Cancer by Downregulating Wnt/β-catenin Signaling.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202203019
Abstract: Although the combination of chemotherapy and immune checkpoint inhibitors (ICIs) can treat triple-negative breast cancer (TNBC), the severe effects of chemotherapy on immune cells significantly reduce the efficacy of the ICIs. Photodynamic therapy (PDT) with… read more here.
Keywords: wnt catenin; triple negative; breast cancer; catenin signaling ... See more keywords
SOX11 regulates apoptosis and cell cycle in hepatocellular carcinoma via Wnt/β‐catenin signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1718
Abstract: Hepatocellular carcinoma (HCC) is the most common type of liver cancer with high mortality. Identifying key molecules involved in the regulation of HCC development is of great clinical significance. SOX11 is a transcription factor belonging… read more here.
Keywords: hepatocellular carcinoma; hcc; catenin signaling; signaling pathway ... See more keywords
Mechano‐regulation of Wnt/β‐Catenin signaling to control paraxial versus lateral mesoderm lineage bifurcation
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Progress"
DOI: 10.1002/btpr.3312
Abstract: Mechanical cues are involved in many biological processes, including embryonic development and patterning. For example, external mechanical forces (shear stress), lateral cell–cell interactions, and mechanical properties (stiffness and composition) of the extracellular matrix are thought… read more here.
Keywords: stress; wnt catenin; catenin signaling; differentiation ... See more keywords
LINC00669 promotes lung adenocarcinoma growth by stimulating the Wnt/β‐catenin signaling pathway
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5604
Abstract: Lung cancer poses severe threats to human health. It is indispensable to discover more druggable molecular targets. We identified a novel dysregulated long non‐coding RNA (lncRNA), LINC00669, in lung adenocarcinoma (LUAD) by analyzing the TCGA… read more here.
Keywords: cell; lung adenocarcinoma; wnt catenin; risk ... See more keywords
Inhibition of MDFI attenuates proliferation and glycolysis of Helicobacter pylori‐infected gastric cancer cells by inhibiting Wnt/β‐catenin pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11907
Abstract: MyoD family inhibitor (MDFI) is a myogenic transcription factor regulatory protein. MDFI has been proven to be upregulated and to promote cell proliferation in colorectal cancer. However, the role of MDFI in gastric cancer (GC)… read more here.
Keywords: cell; proliferation glycolysis; wnt catenin; mdfi ... See more keywords
CircRNF121 knockdown suppresses the progression of cervical cancer by regulating miR‐153‐3p/ATF2 axis and wnt/β‐catenin pathway
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21908
Abstract: Cervical cancer (CC) is a common malignancy in gynecology. Emerging evidence has demonstrated that circular RNAs (circRNAs) act as vital mediators in CC. However, the roles of circRNA ring finger protein 121 (circRNF121) in CC… read more here.
Keywords: cervical cancer; mir 153; wnt catenin; 153 atf2 ... See more keywords
Daphnetin inhibits the survival of hepatocellular carcinoma cells through regulating Wnt/β‐catenin signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21920
Abstract: Evidence has demonstrated that Daphnetin has antiangiogenesis activity, indicating it might be a new multi‐targeted medication for cancer therapy. Here, we aimed to reveal Daphnetin role in hepatocellular carcinoma (HCC) progression and the underlying mechanism.… read more here.
Keywords: wnt catenin; hepatocellular carcinoma; cell; catenin signaling ... See more keywords
Wnt/β‐catenin signaling during early vertebrate neural development
Sign Up to like & getrecommendations! Published in 2017 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22517
Abstract: The vertebrate central nervous system (CNS) is comprised of vast number of distinct cell types arranged in a highly organized manner. This high degree of complexity is achieved by cellular communication, including direct cell‐cell contact,… read more here.
Keywords: vertebrate neural; wnt catenin; neural development; cell ... See more keywords