A molecular mechanism for Wnt ligand-specific signaling
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.aat1178
Abstract: How Wnt ligands achieve specificity Wnt signaling is essential for development, tissue homeostasis, and disease. The 19 members of the Wnt family interact promiscuously with the 10 Frizzled receptors, raising the question of how ligand-specific… read more here.
Keywords: wnt; wnt ligand; wnt7; gpr124 ... See more keywords
Porcupine inhibition disrupts mitochondrial function and homeostasis in WNT ligand-addicted pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cancer therapeutics"
DOI: 10.1158/1535-7163.mct-21-0623
Abstract: WNT signaling promotes pancreatic ductal adenocarcinoma (PDAC) through diverse effects on proliferation, differentiation, survival, and stemness. A subset of PDAC with inactivating mutations in ring finger protein 43 (RNF43) show growth dependency on autocrine WNT… read more here.
Keywords: ligand addicted; wnt; mitochondrial function; wnt ligand ... See more keywords