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   Articles with "wnt ligands" as a keyword



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Canonical and Non-Canonical Wnt Signaling in Immune Cells.

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recommendations! Published in 2018 at "Trends in immunology"

DOI: 10.1016/j.it.2018.08.006

Abstract: Cell differentiation, proliferation, and death are vital for immune homeostasis. Wnt signaling plays essential roles in processes across species. The roles of Wnt signaling proteins and Wnt ligands have been studied in the past, but… read more here.

Keywords: wnt signaling; wnt; immune cells; wnt ligands ... See more keywords

Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem cell self-renewal

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recommendations! Published in 2017 at "Nature"

DOI: 10.1038/nature22313

Abstract: The canonical Wnt/β-catenin signalling pathway governs diverse developmental, homeostatic and pathological processes. Palmitoylated Wnt ligands engage cell-surface frizzled (FZD) receptors and LRP5 and LRP6 co-receptors, enabling β-catenin nuclear translocation and TCF/LEF-dependent gene transactivation. Mutations in… read more here.

Keywords: wnt; rspo ligands; stem cell; stem ... See more keywords
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Wnt signaling in human and mouse breast cancer: Focusing on Wnt ligands, receptors and antagonists

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recommendations! Published in 2018 at "Cancer Science"

DOI: 10.1111/cas.13771

Abstract: Wnt proteins, a group of secreted glycoproteins, mainly combine with receptors Frizzled (FZD) and/or low‐density‐lipoprotein receptor‐related proteins 5/6 (LRP5/6), initiating β‐catenin‐dependent and ‐independent signaling pathways. These pathways, which can be regulated by some secreted antagonists… read more here.

Keywords: wnt signaling; breast cancer; cancer; wnt ligands ... See more keywords
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How Wnt ligands achieve specificity

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recommendations! Published in 2018 at "Science"

DOI: 10.1126/science.361.6403.657-l

Abstract: Developmental Signaling Wnt signaling is essential for development, tissue homeostasis, and disease. The 19 members of the Wnt family interact promiscuously with the 10 Frizzled receptors, raising the question of how ligand-specific discrimination is achieved… read more here.

Keywords: wnt; science; achieve specificity; ligands achieve ... See more keywords
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Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders

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recommendations! Published in 2022 at "Science"

DOI: 10.1126/science.abm4459

Abstract: The blood-brain barrier (BBB) protects the central nervous system (CNS) from harmful blood-borne factors. Although BBB dysfunction is a hallmark of several neurological disorders, therapies to restore BBB function are lacking. An attractive strategy is… read more here.

Keywords: reck; bbb; gpr124 reck; wnt ligands ... See more keywords

WNT ligands contribute to the immune response during septic shock and amplify endotoxemia-driven inflammation in mice.

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recommendations! Published in 2017 at "Blood advances"

DOI: 10.1182/bloodadvances.2017006163

Abstract: Improved understanding of the molecular mechanisms underlying dysregulated inflammatory responses in severe infection and septic shock is urgently needed to improve patient management and identify new therapeutic opportunities. The WNT signaling pathway has been implicated… read more here.

Keywords: response; septic shock; expression; wnt ligands ... See more keywords
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Myeloid Wnt ligands are required for normal development of dermal lymphatic vasculature

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recommendations! Published in 2017 at "PLoS ONE"

DOI: 10.1371/journal.pone.0181549

Abstract: Resident tissue myeloid cells play a role in many aspects of physiology including development of the vascular systems. In the blood vasculature, myeloid cells use VEGFC to promote angiogenesis and can use Wnt ligands to… read more here.

Keywords: myeloid; wnt ligands; myeloid wnt; development dermal ... See more keywords
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Selective Surface and Intraluminal Localization of Wnt Ligands on Small Extracellular Vesicles Released by HT-22 Hippocampal Neurons

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recommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2021.735888

Abstract: The Wnt signaling pathway induces various responses underlying the development and maturation of the nervous system. Wnt ligands are highly hydrophobic proteins that limit their diffusion through an aqueous extracellular medium to a target cell.… read more here.

Keywords: extracellular vesicles; hippocampal neurons; wnt; microscopy ... See more keywords
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Emerging Roles of Wnt Ligands in Human Colorectal Cancer

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recommendations! Published in 2020 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2020.01341

Abstract: Colorectal cancer (CRC) is the fourth leading cause of cancer death worldwide, and constitutive activation of the Wnt signaling pathway is universal in most CRC cases. Wnt ligands (Wnts) are secreted glycoproteins and fundamentally essential… read more here.

Keywords: wnt signaling; roles wnt; emerging roles; colorectal cancer ... See more keywords
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TNF-α Activating Osteoclasts in Patients with Psoriatic Arthritis Enhances the Recruitment of Osteoclast Precursors: A Plausible Role of WNT5A-MCP-1 in Osteoclast Engagement in Psoriatic Arthritis

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23020921

Abstract: Psoriatic arthritis (PsA) results from joint destruction by osteoclasts. The promising efficacy of TNF-α blockage indicates its important role in osteoclastogenesis of PsA. WNT ligands actively regulate osteoclastogenesis. We investigated how WNT ligands activate osteoclasts… read more here.

Keywords: psoriatic arthritis; wnt5a; arthritis; psa patients ... See more keywords

The Roles of Secreted Wnt Ligands in Cancer

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recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24065349

Abstract: Wnt ligands are secreted signaling proteins that display a wide range of biological effects. They play key roles in stimulating Wnt signaling pathways to facilitate processes such as tissue homeostasis and regeneration. Dysregulation of Wnt… read more here.

Keywords: roles secreted; wnt signaling; ligands cancer; wnt ligands ... See more keywords