Medulloblastoma in Adults: Cytogenetic Phenotypes Identify Prognostic Subgroups.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlab020
Abstract: Adult medulloblastomas (MB) are rare. We investigated the genetic landscape and prognostic impact of genetic aberrations in a cohort of 117 adult medulloblastomas. Histological features and pathway activation were evaluated at the protein level; 14.5%… read more here.
Keywords: histology; wnt non; shh; shh mbs ... See more keywords
PATH-32. GENOMIC LANDSCAPE AND BIOLOGY OF MEDULLOBLASTOMA IN ADULTS
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.628
Abstract: Medulloblastoma (MB) is a rare disease in adults. Only few cohorts have been studied so far. Histological features were evaluated and tumors were annotated to WNT-MB, SHH-MB, and non-WNT/non-SHH-MB by immunohistochemistry. Copy number alterations were… read more here.
Keywords: wnt non; non; shh; biology ... See more keywords
Molecular Stratification of Medulloblastoma: Clinical Outcomes and Therapeutic Interventions
Sign Up to like & getrecommendations! Published in 2022 at "AntiCancer Research"
DOI: 10.21873/anticanres.15703
Abstract: Medulloblastoma (MB) is the most common malignant pediatric posterior fossa tumor. Recent genetic, epigenetic, and transcriptomic analyses have classified MB into three subgroups, Wingless Type (WNT), Sonic Hedgehog (SHH), and non-WNT/non-SHH (originally termed Group 3… read more here.
Keywords: non; shh; wnt non; non shh ... See more keywords
The Current Landscape of Targeted Clinical Trials in Non-WNT/Non-SHH Medulloblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14030679
Abstract: Simple Summary Medulloblastoma is a form of malignant brain tumor that arises predominantly in infants and young children and can be divided into different groups based on molecular markers. The group of non-WNT/non-SHH medulloblastoma includes… read more here.
Keywords: shh medulloblastoma; non shh; wnt non; non wnt ... See more keywords