Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients
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DOI: 10.1038/s41467-020-14700-7
Abstract: Current treatments for clear cell renal cell cancer (ccRCC) are insufficient because two-thirds of patients with metastases progress within two years. Here we report the identification and characterization of a cancer stem cell (CSC) population… read more here.
Keywords: cancer stem; wnt notch; cancer; stem ... See more keywords
Sfrp1 Modulates Cell‐signaling Events Underlying Telencephalic Patterning, Growth and Differentiation
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DOI: 10.1093/cercor/bhy013
Abstract: &NA; The mammalian dorsal telencephalic neuroepithelium develops—from medial to lateral—into the choroid plaque, cortical hem, hippocampal primordium and isocortex under the influence of Bmp, Wnt and Notch signaling. Correct telencephalic development requires a tight coordination… read more here.
Keywords: wnt notch; wnt; medio lateral; sfrp1 ... See more keywords
MicroRNA-506 as a tumor suppressor in anaplastic thyroid carcinoma by regulation of WNT and NOTCH signaling pathways
Sign Up to like & getrecommendations! Published in 2023 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2023.69174.15069
Abstract: Objective(s): Anaplastic thyroid carcinoma (ATC) is an aggressive thyroid tumor type that has a poor prognosis due to its high therapeutic resistance. Since ATC accounts for half of thyroid cancer-related deaths, it is required to… read more here.
Keywords: notch signaling; wnt notch; regulation; mir 506 ... See more keywords
Wnt, Notch, and TGF-β Pathways Impinge on Hedgehog Signaling Complexity: An Open Window on Cancer
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DOI: 10.3389/fgene.2019.00711
Abstract: Constitutive activation of the Hedgehog (Hh) signaling pathway is associated with increased risk of developing several malignancies. The biological and pathogenic importance of Hh signaling emphasizes the need to control its action tightly, both physiologically… read more here.
Keywords: signaling pathways; hedgehog signaling; wnt notch; tgf pathways ... See more keywords