Solid pseudopapillary neoplasms of the pancreas are dependent on the Wnt pathway
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12490
Abstract: Solid pseudopapillary neoplasms (SPNs) are rare and relatively indolent tumors of the pancreas. While primary SPNs can be surgically resected, there are currently no therapies available for patients with advanced stage disease. Given that these… read more here.
Keywords: pancreas dependent; neoplasms pancreas; solid pseudopapillary; pseudopapillary neoplasms ... See more keywords
Dact1, a Wnt‐Pathway Inhibitor, Mediates Human Mesangial Cell TGF‐β1‐Induced Apoptosis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25636
Abstract: Chronic kidney disease (CKD) is a worldwide public health problem that affects millions of men and women of all ages and racial groups. Loss of mesangial cells (MC) represents an early common feature in the… read more here.
Keywords: apoptosis; dact1; tgf; cell ... See more keywords
AMBMP activates WNT pathway and alleviates stress-induced behaviors in maternal separation and chronic stress models.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173192
Abstract: Depressive disorders are both prevalent and debilitating, and a proportion of patients have treatment resistance to classic antidepressants. Recent evidence has implicated the intracellular WNT signaling pathway as having a key role in the pathogenesis… read more here.
Keywords: chronic stress; separation chronic; stress; maternal separation ... See more keywords
Experimental tendinopathy treatment with SM04755, a topical small molecule inhibitor of the WNT pathway
Sign Up to like & getrecommendations! Published in 2018 at "Osteoarthritis and Cartilage"
DOI: 10.1016/j.joca.2018.02.064
Abstract: Objectives: SM04755, a novel, topical, small molecule Wnt pathway inhibitor, has previously been shown to inhibit inflammation, reduce fibrosis, and increase tenocyte differentiation in nonclinical models. Two further experiments are presented: 1. SM04755 treatment in… read more here.
Keywords: inhibitor; small molecule; treatment; topical small ... See more keywords
Role of vitamin D in Wnt pathway activation for colonic epithelial cell differentiation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Taibah University Medical Sciences"
DOI: 10.1016/j.jtumed.2021.01.012
Abstract: Objectives Inflammatory bowel disease (IBD) is a medical condition that represents a pathological form of inflammation, causing damage to the colonic mucosa. Adjunctive vitamin D therapy may activate the Wnt/β-catenin pathway that results in cell… read more here.
Keywords: pathway activation; cell differentiation; vitamin; cell ... See more keywords
Pigment epithelium-derived factor, a noninhibitory serine protease inhibitor, is renoprotective by inhibiting the Wnt pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Kidney international"
DOI: 10.1016/j.kint.2016.09.036
Abstract: Pigment epithelium-derived factor (PEDF) expression is downregulated in the kidneys of diabetic rats, and delivery of PEDF suppressed renal fibrotic factors in these animals. PEDF has multiple functions including anti-angiogenic, anti-inflammatory and antifibrotic activities. Since… read more here.
Keywords: tubule epithelial; epithelium derived; pedf; pigment epithelium ... See more keywords
Wnt pathway activation in 3D nephron progenitor culture facilitates self-organization, expansion, and differentiation
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.465
Abstract: and oligodendrocyte precursors as adherent cells. Based on high expression level of Pax6, Sox1, Sox2 and low expression of Pax3 NESCs likely have primitive neural plate identity. Besides spontaneous differentiation in adherent culture, hNESCs are… read more here.
Keywords: expansion; cerebral organoids; differentiation; activation ... See more keywords
Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia"
DOI: 10.1038/leu.2016.232
Abstract: The interaction between vascular endothelial cells (ECs) and cancer cells is of vital importance to understand tumor dissemination. A paradigmatic cancer to study cell–cell interactions is classical Hodgkin Lymphoma (cHL) owing to its complex microenvironment.… read more here.
Keywords: lymphoma; hodgkin lymphoma; canonical wnt; chl ... See more keywords
Bronchopulmonary dysplasia and wnt pathway-associated single nucleotide polymorphisms
Sign Up to like & getrecommendations! Published in 2021 at "Pediatric Research"
DOI: 10.1038/s41390-021-01851-6
Abstract: Genetic variants contribute to the pathogenesis of bronchopulmonary dysplasia (BPD). The aim of this study is to evaluate the association of 45 SNPs with BPD susceptibility in a Turkish premature infant cohort. Infants with gestational… read more here.
Keywords: bpd; level; role; wnt pathway ... See more keywords
Lithium as a possible therapeutic strategy for Cornelia de Lange syndrome
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00414-2
Abstract: Cornelia de Lange Syndrome (CdLS) is a rare developmental disorder affecting a multitude of organs including the central nervous system, inducing a variable neurodevelopmental delay. CdLS malformations derive from the deregulation of developmental pathways, inclusive… read more here.
Keywords: lange syndrome; lithium; lithium possible; cdls ... See more keywords
Identification of RSPO2 Fusion Mutations and Target Therapy Using a Porcupine Inhibitor
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-32652-3
Abstract: Cancers are driven by a variety of somatic gene mutations and identifying these mutations enables the development of novel target drugs. We have sought to identify abnormalities in Wnt pathway-related genes that are sensitive to… read more here.
Keywords: treatment; porcupine inhibitor; rspo2 fusion; fusion ... See more keywords