Articles with "wnt secretion" as a keyword



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SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion

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Published in 2018 at "Nature Communications"

DOI: 10.1038/s41467-018-06114-3

Abstract: Wntless transports Wnt morphogens to the cell surface and is required for Wnt secretion and morphogenic gradients formation. Recycling of endocytosed Wntless requires the sorting nexin-3 (SNX3)-retromer-dependent endosome-to-Golgi transport pathway. Here we demonstrate the essential… read more here.

Keywords: wntless; evolutionary conserved; wnt secretion; snx3 retromer ... See more keywords
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Blockade of Wnt Secretion Attenuates Myocardial Ischemia–Reperfusion Injury by Modulating the Inflammatory Response

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Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms232012252

Abstract: Wnt (a portmanteau of Wingless and Int-1) signaling in the adult heart is largely quiescent. However, there is accumulating evidence that it gets reactivated during the healing process after myocardial infarction (MI). We here tested… read more here.

Keywords: wnt secretion; inflammatory response; wnt; lgk 974 ... See more keywords